Acetyl-coa-directed gene transcription in cancer cells

Inmaculada Martínez-Reyes, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497-511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca2+-NFAT (nuclear factor of activated T cells) signaling.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalGenes and Development
Volume32
Issue number7-8
DOIs
StatePublished - Apr 1 2018

Keywords

  • Acetyl-CoA
  • Calcium
  • Glioblastoma
  • Histone acetylation
  • Metabolism
  • NFAT1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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