Acetyl-coa-directed gene transcription in cancer cells

Inmaculada Martínez-Reyes, Navdeep Chandel*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497-511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca2+-NFAT (nuclear factor of activated T cells) signaling.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalGenes and Development
Volume32
Issue number7-8
DOIs
StatePublished - Apr 1 2018

Fingerprint

Acetyl Coenzyme A
NFATC Transcription Factors
Glioblastoma
Acetylation
Cell Adhesion
Histones
Genes
Cell Movement
Neoplasms
Up-Regulation
Gene Expression

Keywords

  • Acetyl-CoA
  • Calcium
  • Glioblastoma
  • Histone acetylation
  • Metabolism
  • NFAT1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Martínez-Reyes, Inmaculada ; Chandel, Navdeep. / Acetyl-coa-directed gene transcription in cancer cells. In: Genes and Development. 2018 ; Vol. 32, No. 7-8. pp. 463-465.
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Acetyl-coa-directed gene transcription in cancer cells. / Martínez-Reyes, Inmaculada; Chandel, Navdeep.

In: Genes and Development, Vol. 32, No. 7-8, 01.04.2018, p. 463-465.

Research output: Contribution to journalArticle

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