Acetylcholine Neurotransmission in CNS

Marek-Marsel Mesulam*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages1-4
Number of pages4
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Fingerprint

Synaptic Transmission
Cholinergic Agents
Acetylcholine
Alzheimer Disease
Basal Nucleus of Meynert
Neuronal Plasticity
Episodic Memory
Neocortex
Cerebral Cortex
Hippocampus
Cognitive Dysfunction
Basal Forebrain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mesulam, M-M. (2009). Acetylcholine Neurotransmission in CNS. In Encyclopedia of Neuroscience (pp. 1-4). Elsevier Ltd.. https://doi.org/10.1016/B978-008045046-9.00680-X
Mesulam, Marek-Marsel. / Acetylcholine Neurotransmission in CNS. Encyclopedia of Neuroscience. Elsevier Ltd., 2009. pp. 1-4
@inbook{a856a2ff729a472ba4ed5b8b705be836,
title = "Acetylcholine Neurotransmission in CNS",
abstract = "The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.",
author = "Marek-Marsel Mesulam",
year = "2009",
month = "1",
day = "1",
doi = "10.1016/B978-008045046-9.00680-X",
language = "English (US)",
isbn = "9780080450469",
pages = "1--4",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd.",

}

Mesulam, M-M 2009, Acetylcholine Neurotransmission in CNS. in Encyclopedia of Neuroscience. Elsevier Ltd., pp. 1-4. https://doi.org/10.1016/B978-008045046-9.00680-X

Acetylcholine Neurotransmission in CNS. / Mesulam, Marek-Marsel.

Encyclopedia of Neuroscience. Elsevier Ltd., 2009. p. 1-4.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Acetylcholine Neurotransmission in CNS

AU - Mesulam, Marek-Marsel

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

AB - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

UR - http://www.scopus.com/inward/record.url?scp=84882890604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882890604&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00680-X

DO - 10.1016/B978-008045046-9.00680-X

M3 - Chapter

AN - SCOPUS:84882890604

SN - 9780080450469

SP - 1

EP - 4

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd.

ER -