Abstract
The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Neuroscience |
| Publisher | Elsevier Ltd. |
| Pages | 1-4 |
| Number of pages | 4 |
| ISBN (Print) | 9780080450469 |
| DOIs | |
| State | Published - Jan 1 2009 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Acetylcholine Neurotransmission in CNS. / Mesulam, Marek-Marsel.
Encyclopedia of Neuroscience. Elsevier Ltd., 2009. p. 1-4.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Acetylcholine Neurotransmission in CNS
AU - Mesulam, Marek-Marsel
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.
AB - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=84882890604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882890604&partnerID=8YFLogxK
U2 - 10.1016/B978-008045046-9.00680-X
DO - 10.1016/B978-008045046-9.00680-X
M3 - Chapter
AN - SCOPUS:84882890604
SN - 9780080450469
SP - 1
EP - 4
BT - Encyclopedia of Neuroscience
PB - Elsevier Ltd.
ER -