Acetylcholine Neurotransmission in CNS

M. M. Mesulam

doi:10.1016/B978-008045046-9.00680-X

Acetylcholine Neurotransmission in CNS

M. M. Mesulam^*

^*Corresponding author for this work

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	1-4
Number of pages	4
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00680-X
State	Published - Jan 1 2009

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-008045046-9.00680-X

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AB - The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

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Acetylcholine Neurotransmission in CNS

Abstract

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