Acetylcholine Neurotransmission in CNS

M. M. Mesulam*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The hippocampus and cerebral neocortex receive massive cholinergic projections from the basal forebrain. These projections arise predominantly within the nucleus basalis of Meynert, also known as the Ch4 cell group. The cholinergic projection of the cerebral cortex plays a major role in sustaining episodic memory, attention, and experience-induced neuroplasticity. Progressive neurofibrillary degeneration in the nucleus basalis can be seen throughout the continuum that leads from normal aging to mild cognitive impairment and Alzheimer's disease. The resultant perturbation of cortical cholinergic neurotransmission may contribute to the cognitive changes seen in normal aging and Alzheimer's disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages4
ISBN (Print)9780080450469
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Neuroscience(all)


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