Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: Facile cellular triggered release of siRNA

Bong Jin Hong; Anthony J. Chipre; Sonbinh T. Nguyen

doi:10.1021/ja404491r

Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: Facile cellular triggered release of siRNA

Bong Jin Hong, Anthony J. Chipre, Sonbinh T. Nguyen^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals ∼45- and ∼2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

Original language	English (US)
Pages (from-to)	17655-17658
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	47
DOIs	https://doi.org/10.1021/ja404491r
State	Published - Nov 27 2013

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/ja404491r

Cite this

@article{9fcf1c94dcee44b4b3f96e71a75f50b9,

title = "Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: Facile cellular triggered release of siRNA",

abstract = "An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals ∼45- and ∼2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.",

author = "Hong, {Bong Jin} and Chipre, {Anthony J.} and Nguyen, {Sonbinh T.}",

year = "2013",

month = nov,

day = "27",

doi = "10.1021/ja404491r",

language = "English (US)",

volume = "135",

pages = "17655--17658",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "47",

}

TY - JOUR

T1 - Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery

T2 - Facile cellular triggered release of siRNA

AU - Hong, Bong Jin

AU - Chipre, Anthony J.

AU - Nguyen, Sonbinh T.

PY - 2013/11/27

Y1 - 2013/11/27

N2 - An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals ∼45- and ∼2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

AB - An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals ∼45- and ∼2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

UR - http://www.scopus.com/inward/record.url?scp=84889262006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889262006&partnerID=8YFLogxK

U2 - 10.1021/ja404491r

DO - 10.1021/ja404491r

M3 - Article

C2 - 24000948

AN - SCOPUS:84889262006

SN - 0002-7863

VL - 135

SP - 17655

EP - 17658

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 47

ER -

Acid-degradable polymer-caged lipoplex (PCL) platform for siRNA delivery: Facile cellular triggered release of siRNA

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this