Acquired alexithymia following damage to the anterior insula

J. Hogeveen*, G. Bird, A. Chau, F. Krueger, Jordan Henry Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Alexithymia is a subclinical condition characterized by impaired awareness of one's emotional states, which has profound effects on mental health and social interaction. Despite the clinical significance of this condition, the neurocognitive impairment(s) that lead to alexithymia remain unclear. Recent theoretical models suggest that impaired anterior insula (AI) functioning might be involved in alexithymia, but conclusive evidence for this hypothesis is lacking. We measured alexithymia levels in a large sample of brain-injured patients (N=129) and non-brain-injured control participants (N=33), to determine whether alexithymia can be acquired after pronounced damage to the AI. Alexithymia levels were first analysed as a function of group, with patients separated into four groups based on AI damage: patients with >15% damage to AI, patients with <15% damage to AI, patients with no damage to AI, and healthy controls. An ANOVA revealed that alexithymia levels varied across groups (p=0.009), with >15% AI damage causing higher alexithymia relative to all other groups (all p<0.01). Next, a multiple linear regression model was fit with the degree of damage to AI, the degree of damage to a related region (the anterior cingulate cortex, ACC), and the degree of damage to the whole brain as predictor variables, and alexithymia as the dependent variable. Critically, increased AI damage predicted increased alexithymia after controlling for the other two regressors (ACC damage; total lesion volume). Collectively, our results suggest that pronounced AI damage causes increased levels of alexithymia, providing critical evidence that this region supports emotional awareness.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalNeuropsychologia
Volume82
DOIs
StatePublished - Feb 1 2016

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Affective Symptoms
Gyrus Cinguli
Linear Models
Brain
Interpersonal Relations
Mental Health
Theoretical Models

Keywords

  • Alexithymia
  • Anterior cingulate cortex
  • Anterior insula
  • Human lesion study
  • Interoception

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Hogeveen, J. ; Bird, G. ; Chau, A. ; Krueger, F. ; Grafman, Jordan Henry. / Acquired alexithymia following damage to the anterior insula. In: Neuropsychologia. 2016 ; Vol. 82. pp. 142-148.
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Acquired alexithymia following damage to the anterior insula. / Hogeveen, J.; Bird, G.; Chau, A.; Krueger, F.; Grafman, Jordan Henry.

In: Neuropsychologia, Vol. 82, 01.02.2016, p. 142-148.

Research output: Contribution to journalArticle

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