ACSM and CHAMP summit on sickle cell trait: Mitigating risks for warfighters and athletes

Francis G. O'Connor*, Michael F. Bergeron, Joyce Cantrell, Philippe Connes, Kimberly G. Harmon, Edward Ivy, John Kark, Dave Klossner, Peter Lisman, Bryce K. Meyers, Karen O'Brien, Kwaku Ohene-Frempong, Alexis A. Thompson, James Whitehead, Patricia A. Deuster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


INTRODUCTION: An estimated 300 million people worldwide have sickle cell trait (SCT). Although largely benign, SCT has been associated with exertional rhabdomyolysis and exercise-related sudden death in warfighters/athletes (WA). The National Collegiate Athletic Association's policy to confirm a student athlete's SCT status during their preparticipation medical examination prompted reaction from some organizations regarding the rationale and ethical justification of the policy. Methods: On September 26 and 27, 2011, a summit, composed of military and civilian experts in sports medicine and SCT, was convened at the Uniformed Services University in Bethesda, MD. The expert panel was charged with two objectives: 1) to provide specific recommendations to further mitigate the apparent risk with strenuous exercise in WA with SCT and 2) to develop clinical guidelines to identify, treat, and return to duty/play WA suspected to have incurred nonfatal sickle cell collapse. Results: New terminology is introduced, areas of current controversy are explored, consensus recommendations for mitigating risk and managing the WA with SCT are reviewed, and important areas for future research are identified. Conclusion: Further research is needed before conclusions can be drawn regarding the etiology of the increased death rate observed in WA with SCT, and the possibility exists that SCT is a surrogate for as yet another contributing factor for the unexplained deaths.

Original languageEnglish (US)
Pages (from-to)2045-2056
Number of pages12
JournalMedicine and science in sports and exercise
Issue number11
StatePublished - Nov 2012


  • athletic health
  • exercise collapse
  • hemoglobinopathies
  • risk management

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine


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