@article{69ca14485d2c42c08e1b90ec63fed0f8,
title = "ACTH (acthar gel) reduces toxic SOD1 protein linked to amyotrophic lateral sclerosis in transgenic mice: A novel observation",
abstract = "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms. We showed that within a specific dose range, ACTH significantly postponed the disease onset and paralysis in the mouse model. To our surprise and of greater significance is that ACTH significantly reduced the levels of soluble SOD1 in the spinal cord and CNS tissues of G93A-SOD1 treated mice as well as cultured fibroblasts.",
author = "Hasan Arrat and Lukas, {Thomas J.} and Teepu Siddique",
note = "Funding Information: The work was supported in part by Questcor Pharmaceuticals. Additional support was from the Les Turner ALS Foundation, the Les Turner Foundation/Herbert C. Wenske Professorship (to TS), Harold Post Research Professorship (to TS), Vena E. Schaff ALS Research Fund, the S.W. Ranson Fund in ALS Research, and the Foglia Family Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have the following interests. Questcor Pharmaceuticals provided funds to support this project and was the sole source of Acthar gel to be used only in our animal experiments. Questcor is the owner of the drug and has retained rights for its distribution. Questcor is conducting clinical trials for ALS and other diseases. There are no restrictions on data generated during the course of the study. There are no further patents, products in development or marketed products to declare. This does not alter the authors'' adherence to all PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. Publisher Copyright: Copyright {\textcopyright} 2015 Arrat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2015",
month = may,
day = "1",
doi = "10.1371/journal.pone.0125638",
language = "English (US)",
volume = "10",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",
}