Abstract
A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 416-418 |
| Number of pages | 3 |
| Journal | New England Journal of Medicine |
| Volume | 301 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 23 1979 |
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- Medicine(all)
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ACTH Secretion from a Functioning Pheochromocytoma. / Spark, R. F.; Connolly, P. B.; Gluckin, D. S.; White, R.; Sacks, B.; Landsberg, L.
In: New England Journal of Medicine, Vol. 301, No. 8, 23.08.1979, p. 416-418.Research output: Contribution to journal › Article
TY - JOUR
T1 - ACTH Secretion from a Functioning Pheochromocytoma
AU - Spark, R. F.
AU - Connolly, P. B.
AU - Gluckin, D. S.
AU - White, R.
AU - Sacks, B.
AU - Landsberg, L.
PY - 1979/8/23
Y1 - 1979/8/23
N2 - A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.
AB - A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.
UR - http://www.scopus.com/inward/record.url?scp=0018649080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018649080&partnerID=8YFLogxK
U2 - 10.1056/NEJM197908233010807
DO - 10.1056/NEJM197908233010807
M3 - Article
C2 - 223054
AN - SCOPUS:0018649080
VL - 301
SP - 416
EP - 418
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 8
ER -