ACTH Secretion from a Functioning Pheochromocytoma

R. F. Spark, P. B. Connolly, D. S. Gluckin, R. White, B. Sacks, L. Landsberg

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.

Original languageEnglish (US)
Pages (from-to)416-418
Number of pages3
JournalNew England Journal of Medicine
Volume301
Issue number8
DOIs
StatePublished - Aug 23 1979

Fingerprint

Pheochromocytoma
Adrenocorticotropic Hormone
Catecholamines
Veins
Paranoid Disorders
Alkalosis
Hirsutism
Cushing Syndrome
Adrenal Glands
Hyperglycemia
Norepinephrine
Reference Values
Hypertension
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spark, R. F., Connolly, P. B., Gluckin, D. S., White, R., Sacks, B., & Landsberg, L. (1979). ACTH Secretion from a Functioning Pheochromocytoma. New England Journal of Medicine, 301(8), 416-418. https://doi.org/10.1056/NEJM197908233010807
Spark, R. F. ; Connolly, P. B. ; Gluckin, D. S. ; White, R. ; Sacks, B. ; Landsberg, L. / ACTH Secretion from a Functioning Pheochromocytoma. In: New England Journal of Medicine. 1979 ; Vol. 301, No. 8. pp. 416-418.
@article{1136c5978e164452af50f8b8df15f580,
title = "ACTH Secretion from a Functioning Pheochromocytoma",
abstract = "A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.",
author = "Spark, {R. F.} and Connolly, {P. B.} and Gluckin, {D. S.} and R. White and B. Sacks and L. Landsberg",
year = "1979",
month = "8",
day = "23",
doi = "10.1056/NEJM197908233010807",
language = "English (US)",
volume = "301",
pages = "416--418",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "8",

}

Spark, RF, Connolly, PB, Gluckin, DS, White, R, Sacks, B & Landsberg, L 1979, 'ACTH Secretion from a Functioning Pheochromocytoma', New England Journal of Medicine, vol. 301, no. 8, pp. 416-418. https://doi.org/10.1056/NEJM197908233010807

ACTH Secretion from a Functioning Pheochromocytoma. / Spark, R. F.; Connolly, P. B.; Gluckin, D. S.; White, R.; Sacks, B.; Landsberg, L.

In: New England Journal of Medicine, Vol. 301, No. 8, 23.08.1979, p. 416-418.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ACTH Secretion from a Functioning Pheochromocytoma

AU - Spark, R. F.

AU - Connolly, P. B.

AU - Gluckin, D. S.

AU - White, R.

AU - Sacks, B.

AU - Landsberg, L.

PY - 1979/8/23

Y1 - 1979/8/23

N2 - A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.

AB - A PATIENT with hypertension, hirsutism, hyperglycemia, hypokalemic alkalosis and a transient paranoid psychosis was found to have hypercortisolism and increased excretion of catecholamines secondary to an ACTH-secreting pheochromocytoma. Fluctuations in plasma ACTH levels coincided with variations in urinary catecholamine excretion, suggesting that a common factor regulated peptide and catecholamine secretion in this patient. Adrenal-vein sampling revealed fourfold elevations in left-adrenal-vein ACTH and 10-fold elevations in left-adrenal-vein norepinephrine, when these values were compared with samples from the right adrenal vein and peripheral blood. After surgical removal of the left adrenal gland, urinary catecholamine levels returned to the normal range, whereas levels.

UR - http://www.scopus.com/inward/record.url?scp=0018649080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018649080&partnerID=8YFLogxK

U2 - 10.1056/NEJM197908233010807

DO - 10.1056/NEJM197908233010807

M3 - Article

VL - 301

SP - 416

EP - 418

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 8

ER -