Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

Christian Agudelo, Wassim Tarraf, Benson Wu, Douglas M. Wallace, Sanjay R. Patel, Susan Redline, Sonya Kaur, Martha Daviglus, Phyllis C. Zee, Guido Simonelli, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Donglin Zeng, Linda C. Gallo, Hector M. González, Alberto R. Ramos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

Original languageEnglish (US)
Pages (from-to)959-968
Number of pages10
JournalAlzheimer's and Dementia
Issue number6
StatePublished - Jun 2021


  • Hispanic/Latinos
  • actigraphy
  • cognitive decline
  • cohort studies
  • risk factors in epidemiology
  • sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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