Action-effect binding is decreased in motor conversion disorder: Implications for sense of agency

Sarah M. Kranick, James W. Moore, Nadia Yusuf, Valeria T. Martinez, Kathrin LaFaver, Mark J. Edwards, Arpan R. Mehta, Phoebe Collins, Neil A. Harrison, Patrick Haggard, Mark Hallett, Valerie Voon*

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of "self-agency." The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the patient feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder. Twenty patients with motor conversion disorder and 20 age-matched and sex-matched healthy volunteers used a rotating clock to judge the time of their own voluntary key presses (action) and a subsequent auditory tone (effect) after they completed conditioning blocks in which high, medium, and low tones were coupled to images of happy, fearful, and neutral faces. The results replicated those produced previously: it was reported that an effect after a voluntary action occurred earlier, and the preceding action occurred later, compared with trials that used only key presses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores. We demonstrate that patients with motor conversion disorder have decreased action-effect binding for normal voluntary movements compared with healthy volunteers, consistent with the greater experience of lack of control.

Original languageEnglish (US)
Pages (from-to)1110-1116
Number of pages7
JournalMovement Disorders
Volume28
Issue number8
DOIs
StatePublished - Jul 1 2013

Keywords

  • Action-effect binding
  • Agency
  • Conversion disorder
  • Forward model
  • Psychogenic movement disorder

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Kranick, S. M., Moore, J. W., Yusuf, N., Martinez, V. T., LaFaver, K., Edwards, M. J., Mehta, A. R., Collins, P., Harrison, N. A., Haggard, P., Hallett, M., & Voon, V. (2013). Action-effect binding is decreased in motor conversion disorder: Implications for sense of agency. Movement Disorders, 28(8), 1110-1116. https://doi.org/10.1002/mds.25408