Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats

Zhi-Dong Ge; A. W. Zhou; Y. X. Wang; W. P. Li; K. Li; B. Wang; Y. Y. Yao; Z. Chen

Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats

Zhi-Dong Ge^*, A. W. Zhou, Y. X. Wang, W. P. Li, K. Li, B. Wang, Y. Y. Yao, Z. Chen

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

AIM: Effect of ipriflavone on vitamin A acid-induced osteoporosis in rats was studied. METHODS: Vitamin A acid was used to induce osteoporosis in rats. RESULTS: Vitamin A acid 70 mg · kg^-1 · d^-1 markedly de- creased the calcium and phosphorus contents of femora, and serum phosphorus, and significantly increased uninary calcium. Microdensitometrical analysis of roentgenography indicated that vitamin A acid 70 mg · kg^-1 · d^-1 noticeably reduced the density of both distal metaphyses and diaphyses of femora. When ipriflavone at the doses of 50, 100, 200 mg · kg^-1 · d^-1 was intragastrically administered to rats, it was found that the above- mentioned changes induced by vitamin A acid were dose-dependently inhibited. In addition, ipriflavone at the doses of 50, 100 · 200 mg · kg^-1 · d^- ¹ showed marked elevating effect on serum calcium in rats. CONCLUSION: Ipriflavone is effective in preventing and treating osteoporosis in rats induced by vitamin A acid.

Original language	English (US)
Pages (from-to)	447-449
Number of pages	3
Journal	Chinese Pharmacological Bulletin
Volume	13
Issue number	5
State	Published - 1997

Keywords

Calcium
Ipriflavone
Microdensitometric analysis
Osteoporosis
Phosphorus
Vitamin A acid

ASJC Scopus subject areas

Pharmacology

Cite this

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title = "Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats",

abstract = "AIM: Effect of ipriflavone on vitamin A acid-induced osteoporosis in rats was studied. METHODS: Vitamin A acid was used to induce osteoporosis in rats. RESULTS: Vitamin A acid 70 mg · kg-1 · d-1 markedly de- creased the calcium and phosphorus contents of femora, and serum phosphorus, and significantly increased uninary calcium. Microdensitometrical analysis of roentgenography indicated that vitamin A acid 70 mg · kg-1 · d-1 noticeably reduced the density of both distal metaphyses and diaphyses of femora. When ipriflavone at the doses of 50, 100, 200 mg · kg-1 · d-1 was intragastrically administered to rats, it was found that the above- mentioned changes induced by vitamin A acid were dose-dependently inhibited. In addition, ipriflavone at the doses of 50, 100 · 200 mg · kg-1 · d- 1 showed marked elevating effect on serum calcium in rats. CONCLUSION: Ipriflavone is effective in preventing and treating osteoporosis in rats induced by vitamin A acid.",

keywords = "Calcium, Ipriflavone, Microdensitometric analysis, Osteoporosis, Phosphorus, Vitamin A acid",

author = "Zhi-Dong Ge and Zhou, {A. W.} and Wang, {Y. X.} and Li, {W. P.} and K. Li and B. Wang and Yao, {Y. Y.} and Z. Chen",

year = "1997",

language = "English (US)",

volume = "13",

pages = "447--449",

journal = "Chinese Pharmacological Bulletin",

issn = "1001-1978",

publisher = "Institute of Clinical Pharmacology",

number = "5",

}

TY - JOUR

T1 - Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats

AU - Ge, Zhi-Dong

AU - Zhou, A. W.

AU - Wang, Y. X.

AU - Li, W. P.

AU - Li, K.

AU - Wang, B.

AU - Yao, Y. Y.

AU - Chen, Z.

PY - 1997

Y1 - 1997

N2 - AIM: Effect of ipriflavone on vitamin A acid-induced osteoporosis in rats was studied. METHODS: Vitamin A acid was used to induce osteoporosis in rats. RESULTS: Vitamin A acid 70 mg · kg-1 · d-1 markedly de- creased the calcium and phosphorus contents of femora, and serum phosphorus, and significantly increased uninary calcium. Microdensitometrical analysis of roentgenography indicated that vitamin A acid 70 mg · kg-1 · d-1 noticeably reduced the density of both distal metaphyses and diaphyses of femora. When ipriflavone at the doses of 50, 100, 200 mg · kg-1 · d-1 was intragastrically administered to rats, it was found that the above- mentioned changes induced by vitamin A acid were dose-dependently inhibited. In addition, ipriflavone at the doses of 50, 100 · 200 mg · kg-1 · d- 1 showed marked elevating effect on serum calcium in rats. CONCLUSION: Ipriflavone is effective in preventing and treating osteoporosis in rats induced by vitamin A acid.

AB - AIM: Effect of ipriflavone on vitamin A acid-induced osteoporosis in rats was studied. METHODS: Vitamin A acid was used to induce osteoporosis in rats. RESULTS: Vitamin A acid 70 mg · kg-1 · d-1 markedly de- creased the calcium and phosphorus contents of femora, and serum phosphorus, and significantly increased uninary calcium. Microdensitometrical analysis of roentgenography indicated that vitamin A acid 70 mg · kg-1 · d-1 noticeably reduced the density of both distal metaphyses and diaphyses of femora. When ipriflavone at the doses of 50, 100, 200 mg · kg-1 · d-1 was intragastrically administered to rats, it was found that the above- mentioned changes induced by vitamin A acid were dose-dependently inhibited. In addition, ipriflavone at the doses of 50, 100 · 200 mg · kg-1 · d- 1 showed marked elevating effect on serum calcium in rats. CONCLUSION: Ipriflavone is effective in preventing and treating osteoporosis in rats induced by vitamin A acid.

KW - Calcium

KW - Ipriflavone

KW - Microdensitometric analysis

KW - Osteoporosis

KW - Phosphorus

KW - Vitamin A acid

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M3 - Article

AN - SCOPUS:0031453879

SN - 1001-1978

VL - 13

SP - 447

EP - 449

JO - Chinese Pharmacological Bulletin

JF - Chinese Pharmacological Bulletin

IS - 5

ER -

Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats

Abstract

Keywords

ASJC Scopus subject areas

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