Activation and habituation in olfaction - An fMRI study

Alexander Poellinger*, Robert Thomas, Peter Lio, Anne Lee, Nikos Makris, Bruce R. Rosen, Kenneth K. Kwong

*Corresponding author for this work

Research output: Contribution to journalArticle

244 Scopus citations

Abstract

This study investigated human BOLD responses in primary and higher order olfactory cortices following presentation of short- and long-duration odorant stimuli using a 3-T MR scanner. The goal was to identify temporal differences in the course of the response that might underlie habituation. A short-duration stimulus (9 s) consistently activated the primary olfactory cortex (POC). After a long stimulus (60 s), the temporal form of the response differed in different parts of the olfactory network: (1) The POC (piriform, entorhinal cortex, amygdala) and, interestingly, the hippocampus and, to a certain degree, the anterior insula show a short, phasic increase in the signal, followed by a prolonged decrease below baseline. (2) In the orbitofrontal cortex a sustained increase in activation was seen. This increase lasted approximately as long as the duration of odorant presentation (∼60 s). (3) The mediodorsal nucleus of the thalamus and the caudate nucleus responded with an increase in signal which returned to baseline after approximately 15 to 30 s. The correlated biphasic hemodynamic response in the POC, hippocampus, and anterior insula during prolonged olfactory stimulation suggests that these three areas may interact closely with each other in the control of habituation. These results extend recent data which showed habituation of the rat piriform cortex and dissociation between the POC and the orbitofrontal cortex.

Original languageEnglish (US)
Pages (from-to)547-560
Number of pages14
JournalNeuroimage
Volume13
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Brain mapping
  • Habituation
  • Human
  • Magnetic resonance imaging
  • Neurons
  • Odorant
  • Odors
  • Olfactory pathways
  • Physiological
  • Physiology
  • Reaction time
  • Stimulation

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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