Activation and inhibition of JAK-STAT signal transduction by RNA viruses

Curt M Horvath*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The investigation of interferon (IFN)-stimulated signal transduction leading to antiviral gene expression revealed the first members of the JAK and STAT protein families. The importance of IFN signaling in the innate cellular response to virus infection is highlighted by the evolution of numerous virus-encoded IFN evasion strategies that can prevent IFN production or antagonize downstream responses. Some RNA viruses in the family Paramyxoviridae have evolved the ability to target STAT proteins directly to eliminate antiviral signaling, preventing IFN-stimulated gene expression and innate antiviral responses. The virus-encoded STAT inhibitors are highly homologous to each other, and target STATs through protein interactions. However, in-depth investigations of the biochemical and cellular mechanisms have revealed that individual paramyxovirus genera have evolved distinct mechanisms to mediate STAT destruction.

Original languageEnglish (US)
Title of host publicationJak-Stat Signaling
Subtitle of host publicationFrom Basics to Disease
PublisherSpringer-Verlag Wien
Number of pages15
ISBN (Electronic)9783709108918
ISBN (Print)370910890X, 9783709108901
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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