Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins

Karla J. Fullner Satchell*

*Corresponding author for this work

Research output: Contribution to journalShort survey

28 Scopus citations

Abstract

Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.

Original languageEnglish (US)
Pages (from-to)1241-1247
Number of pages7
JournalMicrobes and Infection
Volume5
Issue number13
DOIs
StatePublished - Nov 2003

Keywords

  • Cytokines
  • Dendritic cells
  • MKP-1
  • Macrophage
  • RTX toxin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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