Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins

Karla J. Fullner Satchell

doi:10.1016/j.micinf.2003.08.007

Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins

Karla J. Fullner Satchell^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Short survey › peer-review

30 Scopus citations

Abstract

Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.

Original language	English (US)
Pages (from-to)	1241-1247
Number of pages	7
Journal	Microbes and Infection
Volume	5
Issue number	13
DOIs	https://doi.org/10.1016/j.micinf.2003.08.007
State	Published - Nov 2003

Funding

I thank Alan Hauser and Steve Miller for reading the manuscript. K.J.F.S. is supported by the Biomedical Research Support Program of the Howard Hughes Medical Institute and NIH grant AI051490.

Keywords

Cytokines
Dendritic cells
MKP-1
Macrophage
RTX toxin

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2003.08.007

Cite this

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title = "Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins",

abstract = "Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.",

keywords = "Cytokines, Dendritic cells, MKP-1, Macrophage, RTX toxin",

author = "{Fullner Satchell}, {Karla J.}",

note = "Funding Information: I thank Alan Hauser and Steve Miller for reading the manuscript. K.J.F.S. is supported by the Biomedical Research Support Program of the Howard Hughes Medical Institute and NIH grant AI051490.",

year = "2003",

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doi = "10.1016/j.micinf.2003.08.007",

language = "English (US)",

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journal = "Microbes and Infection",

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T1 - Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins

AU - Fullner Satchell, Karla J.

N1 - Funding Information: I thank Alan Hauser and Steve Miller for reading the manuscript. K.J.F.S. is supported by the Biomedical Research Support Program of the Howard Hughes Medical Institute and NIH grant AI051490.

PY - 2003/11

Y1 - 2003/11

N2 - Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.

AB - Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.

KW - Cytokines

KW - Dendritic cells

KW - MKP-1

KW - Macrophage

KW - RTX toxin

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U2 - 10.1016/j.micinf.2003.08.007

DO - 10.1016/j.micinf.2003.08.007

M3 - Short survey

C2 - 14623020

AN - SCOPUS:0242653921

SN - 1286-4579

VL - 5

SP - 1241

EP - 1247

JO - Microbes and Infection

JF - Microbes and Infection

IS - 13

ER -

Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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