A series of regioselective di- and trifunctionalized pillararene derivatives have been synthesized by a deprotection-followed-by-activation strategy, and their constitutions have been established as a result of having access to their solid-state structures. De-O-methylation occurs in a stepwise manner at lower temperatures under kinetic control, affording the desired oligo-substituted pillararene derivatives. In addition, the regioisomers of these derivatives can be isolated by installing triflate groups on the free hydroxyl groups. (Chemical Equation Presented).
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry