Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress

Chie Kanei-Ishii, Jun Tanikawa, Akira Nakai, Richard I. Morimoto, Shunsuke Ishii*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

In vertebrates, the presence of multiple heat shock transcription factors (HSFs) indicates that these factors may be regulated by distinct stress signals. HSF3 was specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb). These factors formed a complex through their DNA binding domains that stimulated the nuclear entry and formation of the transcriptionally active trimer of HSF3. Because c-Myb participates in cellular proliferation, this regulatory pathway may provide a link between cellular proliferation and the stress response.

Original languageEnglish (US)
Pages (from-to)246-248
Number of pages3
JournalScience
Volume277
Issue number5323
DOIs
StatePublished - Jul 11 1997

ASJC Scopus subject areas

  • General

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