Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

Sarah E. LeBoeuf; Warren L. Wu; Triantafyllia R. Karakousi; Burcu Karadal; S. Ra Elle Jackson; Shawn M. Davidson; Kwok Kin Wong; Sergei B. Koralov; Volkan I. Sayin; Thales Papagiannakopoulos

doi:10.1016/j.cmet.2019.11.012

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

Sarah E. LeBoeuf, Warren L. Wu, Triantafyllia R. Karakousi, Burcu Karadal, S. Ra Elle Jackson, Shawn M. Davidson, Kwok Kin Wong, Sergei B. Koralov, Volkan I. Sayin, Thales Papagiannakopoulos^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

LeBoeuf et al. describe a general mechanism through which cancer cells depend on non-essential amino acids. Tumor cells with intrinsically low intracellular glutamate require amino acids to be supplied from the extracellular environment. By reducing the amount of circulating amino acids, the authors reduce tumor growth in vivo.

Original language	English (US)
Pages (from-to)	339-350.e4
Journal	Cell Metabolism
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2019.11.012
State	Published - Feb 4 2020

Keywords

Keap1
NRF2
amino acid synthesis
asparaginase
glutamate
glutaminase
lung cancer
metabolism
non-essential amino acids
oxidative stress
system x

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2019.11.012

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LeBoeuf, S. E., Wu, W. L., Karakousi, T. R., Karadal, B., Jackson, S. R. E., Davidson, S. M., Wong, K. K., Koralov, S. B., Sayin, V. I., & Papagiannakopoulos, T. (2020). Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids. Cell Metabolism, 31(2), 339-350.e4. https://doi.org/10.1016/j.cmet.2019.11.012

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abstract = "LeBoeuf et al. describe a general mechanism through which cancer cells depend on non-essential amino acids. Tumor cells with intrinsically low intracellular glutamate require amino acids to be supplied from the extracellular environment. By reducing the amount of circulating amino acids, the authors reduce tumor growth in vivo.",

keywords = "Keap1, NRF2, amino acid synthesis, asparaginase, glutamate, glutaminase, lung cancer, metabolism, non-essential amino acids, oxidative stress, system x",

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AU - Karadal, Burcu

AU - Jackson, S. Ra Elle

AU - Davidson, Shawn M.

AU - Wong, Kwok Kin

AU - Koralov, Sergei B.

AU - Sayin, Volkan I.

AU - Papagiannakopoulos, Thales

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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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