Activation of the Immune Coagulation System by Murine Hepatitis Virus Strain 3

G. Levy, M. Abecassis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Viral infections result in alterations in hemostasis and coagulation. It has previously been shown that susceptibility to murine hepatitis virus strain 3 (MHV-3), a coronavirus, correlates directly with the spontaneous, T lymphocyte-instructed expression of a procoagulant monokine that exhibits prothrombin-cleaving activity (procoagulant activity [PCA]). A biologic role for PCA in the pathogenesis of MHV-3 infection is suggested by results of in vivo microscopic observations made during acute MHV-3 infection. Recently, it has been demonstrated that prostaglandin E2 abrogates the induction of PCA by MHV-3 both in vivo and in vitro and prevents hepatic necrosis and the associated microcirculatory changes. These data suggest that MHV-3 induces cellular injury through the activation of the coagulation cascade and provide further evidence for a role for PCA in the pathogenesis of MHV-3 infection.

Original languageEnglish (US)
Pages (from-to)712-721
Number of pages10
JournalReviews of infectious diseases
Volume11
DOIs
StatePublished - May 1989

ASJC Scopus subject areas

  • Microbiology (medical)

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