Immunologically mediated, immediate-type respiratory responses in rhesus monkeys were studied by a variety of parameters of pulmonary function. The respiratory responses were either reagin-mediated reactions to ascaris antigen or reverse passive respiratory reactions induced by anti-IgE. In 18 out of 32 experiments using ascaris aerosol there was a significant increase in pulmonary resistance (R1). The measurement of R1 in these responses appears more sensitive in detecting these reactions than the previously described parameters using flow tracings alone. Eleven responses to aerosol challenge were characterized by increased breathing frequency (f) and decreases in dynamic compliance (Cdyn.). These 11 reciprocal f-Cdyn. changes occurred without parallel increase in R1. The f-Cdyn. changes are interpreted as positive responses to antigen or anti-IgE aerosol challenge. These respiratory response systems are considered to be analogous to human asthma in certain immunologic and physiologic characteristics.
|Original language||English (US)|
|Number of pages||12|
|Journal||The Journal of Laboratory and Clinical Medicine|
|State||Published - Jan 1 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine