Acute airway obstruction in rhesus monkeys induced by pharmacologic and immunologic stimuli

Joseph F. Kelly, David W. Cugell, Roy Patterson*, Kathleen E. Harris

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Immunologically mediated, immediate-type respiratory responses in rhesus monkeys were studied by a variety of parameters of pulmonary function. The respiratory responses were either reagin-mediated reactions to ascaris antigen or reverse passive respiratory reactions induced by anti-IgE. In 18 out of 32 experiments using ascaris aerosol there was a significant increase in pulmonary resistance (R1). The measurement of R1 in these responses appears more sensitive in detecting these reactions than the previously described parameters using flow tracings alone. Eleven responses to aerosol challenge were characterized by increased breathing frequency (f) and decreases in dynamic compliance (Cdyn.). These 11 reciprocal f-Cdyn. changes occurred without parallel increase in R1. The f-Cdyn. changes are interpreted as positive responses to antigen or anti-IgE aerosol challenge. These respiratory response systems are considered to be analogous to human asthma in certain immunologic and physiologic characteristics.

Original languageEnglish (US)
Pages (from-to)738-749
Number of pages12
JournalThe Journal of Laboratory and Clinical Medicine
Volume83
Issue number5
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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