Acute brain infarcts after spontaneous intracerebral hemorrhage: A diffusion-weighted imaging study

Shyam Prabhakaran*, Rajesh Gupta, Bichun Ouyang, Sayona John, Richard E. Temes, Yousef Mohammad, Vivien H. Lee, Thomas P. Bleck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

BACKGROUND AND PURPOSE-: We aimed to determine the prevalence of acute brain infarcts using diffusion-weighted imaging (DWI) in patients with spontaneous intracerebral hemorrhage (ICH). METHODS-: We collected data on consecutive patients with spontaneous ICH admitted to our institution between August 1, 2006 and December 31, 2008 and in whom DWI was performed within 28 days of admission. Patients with hemorrhage attributable to trauma, tumor, aneurysm, vascular malformation, and hemorrhagic conversion of arterial or venous infarction were excluded. Restricted diffusion within, contiguous with, or immediately neighboring the hematoma or chronic infarcts was not considered abnormal. Using multivariable logistic regression, we evaluated potential predictors of DWI abnormality including clinical and radiographic characteristics and treatments. A probability value <0.05 was considered significant in the final model. RESULTS-: Among 118 spontaneous ICH patients (mean 59.6 years, 47.5% male, and 31.4% white) who also underwent MRI, DWI abnormality was observed in 22.9%. The majority of infarcts were small (median volume 0.25 mL), subcortical (70.4%), and subclinical (88.9%). Factors independently associated with DWI abnormality were prior ischemic stroke (P=0.002), MAP lowering by ≥40% (P=0.004), and craniotomy for ICH evacuation (P=0.001). CONCLUSION-: We found that acute brain infarction is relatively common after acute spontaneous ICH. Several factors, including aggressive blood pressure lowering, may be associated with acute ischemic infarcts after ICH. These preliminary findings require further prospective study.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalStroke
Volume41
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Antihypertensive therapy
  • Cerebral blood flow
  • Subclinical infarction

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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