Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Shuang Zhang; Xin Yi Yeap; Matthew DeBerge; Nivedita K. Naresh; Kevin Wang; Zhengxin Jiang; Jane E. Wilcox; Steven M. White; John P. Morrow; Paul W. Burridge; Daniel Procissi; Evan A. Scott; William Frazier; Edward B. Thorp

doi:10.1016/j.jacbts.2017.03.013

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Shuang Zhang, Xin Yi Yeap, Matthew DeBerge, Nivedita K. Naresh, Kevin Wang, Zhengxin Jiang, Jane E. Wilcox, Steven M. White, John P. Morrow, Paul W. Burridge, Daniel Procissi, Evan A. Scott, William Frazier, Edward B. Thorp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

Original language	English (US)
Pages (from-to)	386-397
Number of pages	12
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.jacbts.2017.03.013
State	Published - Aug 2017

Keywords

CD47
macrophage
phagocytosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Zhang, S., Yeap, X. Y., DeBerge, M., Naresh, N. K., Wang, K., Jiang, Z., Wilcox, J. E., White, S. M., Morrow, J. P., Burridge, P. W., Procissi, D., Scott, E. A., Frazier, W., & Thorp, E. B. (2017). Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC: Basic to Translational Science, 2(4), 386-397. https://doi.org/10.1016/j.jacbts.2017.03.013

Zhang, Shuang ; Yeap, Xin Yi ; DeBerge, Matthew ; Naresh, Nivedita K. ; Wang, Kevin ; Jiang, Zhengxin ; Wilcox, Jane E. ; White, Steven M. ; Morrow, John P. ; Burridge, Paul W. ; Procissi, Daniel ; Scott, Evan A. ; Frazier, William ; Thorp, Edward B. / Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. In: JACC: Basic to Translational Science. 2017 ; Vol. 2, No. 4. pp. 386-397.

@article{86e174b2ee954636a0a14071fb5fb340,

title = "Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair",

abstract = "Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.",

keywords = "CD47, macrophage, phagocytosis",

author = "Shuang Zhang and Yeap, {Xin Yi} and Matthew DeBerge and Naresh, {Nivedita K.} and Kevin Wang and Zhengxin Jiang and Wilcox, {Jane E.} and White, {Steven M.} and Morrow, {John P.} and Burridge, {Paul W.} and Daniel Procissi and Scott, {Evan A.} and William Frazier and Thorp, {Edward B.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = aug,

doi = "10.1016/j.jacbts.2017.03.013",

language = "English (US)",

volume = "2",

pages = "386--397",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

number = "4",

}

Zhang, S, Yeap, XY, DeBerge, M, Naresh, NK, Wang, K, Jiang, Z, Wilcox, JE, White, SM, Morrow, JP, Burridge, PW , Procissi, D , Scott, EA, Frazier, W & Thorp, EB 2017, 'Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair', JACC: Basic to Translational Science, vol. 2, no. 4, pp. 386-397. https://doi.org/10.1016/j.jacbts.2017.03.013

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. / Zhang, Shuang; Yeap, Xin Yi; DeBerge, Matthew; Naresh, Nivedita K.; Wang, Kevin; Jiang, Zhengxin; Wilcox, Jane E.; White, Steven M.; Morrow, John P.; Burridge, Paul W.; Procissi, Daniel ; Scott, Evan A.; Frazier, William; Thorp, Edward B.

In: JACC: Basic to Translational Science, Vol. 2, No. 4, 08.2017, p. 386-397.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

AU - Zhang, Shuang

AU - Yeap, Xin Yi

AU - DeBerge, Matthew

AU - Naresh, Nivedita K.

AU - Wang, Kevin

AU - Jiang, Zhengxin

AU - Wilcox, Jane E.

AU - White, Steven M.

AU - Morrow, John P.

AU - Burridge, Paul W.

AU - Procissi, Daniel

AU - Scott, Evan A.

AU - Frazier, William

AU - Thorp, Edward B.

PY - 2017/8

Y1 - 2017/8

N2 - Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

AB - Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

KW - CD47

KW - macrophage

KW - phagocytosis

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DO - 10.1016/j.jacbts.2017.03.013

M3 - Article

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AN - SCOPUS:85027548555

VL - 2

SP - 386

EP - 397

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 4

ER -

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Abstract

Keywords

ASJC Scopus subject areas

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