Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Shuang Zhang, Xin Yi Yeap, Matthew DeBerge, Nivedita K. Naresh, Kevin Wang, Zhengxin Jiang, Jane E Wilcox, Steven M White, John P. Morrow, Paul Burridge, Daniele Procissi, Evan Alexander Scott, William Frazier, Edward Benjamin Thorp*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

Original languageEnglish (US)
Pages (from-to)386-397
Number of pages12
JournalJACC: Basic to Translational Science
Volume2
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Myocardial Reperfusion
Phagocytosis
Cardiac Myocytes
Blocking Antibodies
Phagocytes
Integrins
Reperfusion
Myocardial Ischemia
Myocardium
Macrophages
Myocardial Infarction
Inflammation
Wounds and Injuries
Proteins

Keywords

  • CD47
  • macrophage
  • phagocytosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Zhang, Shuang ; Yeap, Xin Yi ; DeBerge, Matthew ; Naresh, Nivedita K. ; Wang, Kevin ; Jiang, Zhengxin ; Wilcox, Jane E ; White, Steven M ; Morrow, John P. ; Burridge, Paul ; Procissi, Daniele ; Scott, Evan Alexander ; Frazier, William ; Thorp, Edward Benjamin. / Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. In: JACC: Basic to Translational Science. 2017 ; Vol. 2, No. 4. pp. 386-397.
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abstract = "Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.",
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Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. / Zhang, Shuang; Yeap, Xin Yi; DeBerge, Matthew; Naresh, Nivedita K.; Wang, Kevin; Jiang, Zhengxin; Wilcox, Jane E; White, Steven M; Morrow, John P.; Burridge, Paul; Procissi, Daniele; Scott, Evan Alexander; Frazier, William; Thorp, Edward Benjamin.

In: JACC: Basic to Translational Science, Vol. 2, No. 4, 01.08.2017, p. 386-397.

Research output: Contribution to journalArticle

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AU - Zhang, Shuang

AU - Yeap, Xin Yi

AU - DeBerge, Matthew

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AU - Wang, Kevin

AU - Jiang, Zhengxin

AU - Wilcox, Jane E

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AU - Frazier, William

AU - Thorp, Edward Benjamin

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AB - Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

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