Abstract
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 386-397 |
| Number of pages | 12 |
| Journal | JACC: Basic to Translational Science |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2017 |
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Keywords
- CD47
- macrophage
- phagocytosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
}
Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. / Zhang, Shuang; Yeap, Xin Yi; DeBerge, Matthew; Naresh, Nivedita K.; Wang, Kevin; Jiang, Zhengxin; Wilcox, Jane E.; White, Steven M.; Morrow, John P.; Burridge, Paul W.; Procissi, Daniel; Scott, Evan A.; Frazier, William; Thorp, Edward B.
In: JACC: Basic to Translational Science, Vol. 2, No. 4, 08.2017, p. 386-397.Research output: Contribution to journal › Article
TY - JOUR
T1 - Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
AU - Zhang, Shuang
AU - Yeap, Xin Yi
AU - DeBerge, Matthew
AU - Naresh, Nivedita K.
AU - Wang, Kevin
AU - Jiang, Zhengxin
AU - Wilcox, Jane E.
AU - White, Steven M.
AU - Morrow, John P.
AU - Burridge, Paul W.
AU - Procissi, Daniel
AU - Scott, Evan A.
AU - Frazier, William
AU - Thorp, Edward B.
PY - 2017/8
Y1 - 2017/8
N2 - Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.
AB - Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.
KW - CD47
KW - macrophage
KW - phagocytosis
UR - http://www.scopus.com/inward/record.url?scp=85027548555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027548555&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2017.03.013
DO - 10.1016/j.jacbts.2017.03.013
M3 - Article
C2 - 28920097
AN - SCOPUS:85027548555
VL - 2
SP - 386
EP - 397
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 4
ER -