Acute chest syndrome is associated with history of asthma in hemoglobin SC disease

Elana Y. Poulter, Piotr Truszkowski, Alexis A Thompson, Robert I Liem*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Acute chest syndrome (ACS) is a frequent cause of morbidity and leading cause of death among individuals with sickle cell disease. Yet, ACS in hemoglobin SC disease is not well characterized. The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease. Procedure: We retrospectively reviewed 71 inpatient episodes of ACS in patients with hemoglobin SC disease over a 20-year period. Continuous and categorical data from index cases were compared with that from 71 control cases of ACS in patients with hemoglobin SS disease. Results: Median length of hospitalization was shorter for hemoglobin SC episodes when compared to hemoglobin SS episodes (3.0 vs. 5.0 days, P<0.001). In comparison to hemoglobin SS patients, a greater proportion of hemoglobin SC patients had a previous history of asthma or wheezing (50.7 vs. 33.8%, OR=2.01 [1.02-3.96], P=0.041) and a respiratory complaint of wheeze (11.3 vs. 2.8%, OR=4.38 [0.90-21.4], P=0.049). In our multivariate regression model, time to ACS diagnosis and total number of days of oxygen supplementation were independent predictors of length of hospitalization in both hemoglobin SC and SS episodes of ACS. Conclusions: ACS appears to be less severe in children with hemoglobin SC disease compared to that in children with SS disease. Asthma and wheezing may represent more significant risk factors for the development of ACS in children with hemoglobin SC disease.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalPediatric Blood and Cancer
Volume57
Issue number2
DOIs
StatePublished - Aug 1 2011

Fingerprint

Hemoglobin SC Disease
Acute Chest Syndrome
Asthma
Sickle Hemoglobin
Respiratory Sounds
Hemoglobins
Hospitalization
Sickle Cell Anemia
Inpatients
Cause of Death

Keywords

  • Acute chest syndrome
  • Asthma
  • Sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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title = "Acute chest syndrome is associated with history of asthma in hemoglobin SC disease",
abstract = "Background: Acute chest syndrome (ACS) is a frequent cause of morbidity and leading cause of death among individuals with sickle cell disease. Yet, ACS in hemoglobin SC disease is not well characterized. The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease. Procedure: We retrospectively reviewed 71 inpatient episodes of ACS in patients with hemoglobin SC disease over a 20-year period. Continuous and categorical data from index cases were compared with that from 71 control cases of ACS in patients with hemoglobin SS disease. Results: Median length of hospitalization was shorter for hemoglobin SC episodes when compared to hemoglobin SS episodes (3.0 vs. 5.0 days, P<0.001). In comparison to hemoglobin SS patients, a greater proportion of hemoglobin SC patients had a previous history of asthma or wheezing (50.7 vs. 33.8{\%}, OR=2.01 [1.02-3.96], P=0.041) and a respiratory complaint of wheeze (11.3 vs. 2.8{\%}, OR=4.38 [0.90-21.4], P=0.049). In our multivariate regression model, time to ACS diagnosis and total number of days of oxygen supplementation were independent predictors of length of hospitalization in both hemoglobin SC and SS episodes of ACS. Conclusions: ACS appears to be less severe in children with hemoglobin SC disease compared to that in children with SS disease. Asthma and wheezing may represent more significant risk factors for the development of ACS in children with hemoglobin SC disease.",
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Acute chest syndrome is associated with history of asthma in hemoglobin SC disease. / Poulter, Elana Y.; Truszkowski, Piotr; Thompson, Alexis A; Liem, Robert I.

In: Pediatric Blood and Cancer, Vol. 57, No. 2, 01.08.2011, p. 289-293.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute chest syndrome is associated with history of asthma in hemoglobin SC disease

AU - Poulter, Elana Y.

AU - Truszkowski, Piotr

AU - Thompson, Alexis A

AU - Liem, Robert I

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N2 - Background: Acute chest syndrome (ACS) is a frequent cause of morbidity and leading cause of death among individuals with sickle cell disease. Yet, ACS in hemoglobin SC disease is not well characterized. The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease. Procedure: We retrospectively reviewed 71 inpatient episodes of ACS in patients with hemoglobin SC disease over a 20-year period. Continuous and categorical data from index cases were compared with that from 71 control cases of ACS in patients with hemoglobin SS disease. Results: Median length of hospitalization was shorter for hemoglobin SC episodes when compared to hemoglobin SS episodes (3.0 vs. 5.0 days, P<0.001). In comparison to hemoglobin SS patients, a greater proportion of hemoglobin SC patients had a previous history of asthma or wheezing (50.7 vs. 33.8%, OR=2.01 [1.02-3.96], P=0.041) and a respiratory complaint of wheeze (11.3 vs. 2.8%, OR=4.38 [0.90-21.4], P=0.049). In our multivariate regression model, time to ACS diagnosis and total number of days of oxygen supplementation were independent predictors of length of hospitalization in both hemoglobin SC and SS episodes of ACS. Conclusions: ACS appears to be less severe in children with hemoglobin SC disease compared to that in children with SS disease. Asthma and wheezing may represent more significant risk factors for the development of ACS in children with hemoglobin SC disease.

AB - Background: Acute chest syndrome (ACS) is a frequent cause of morbidity and leading cause of death among individuals with sickle cell disease. Yet, ACS in hemoglobin SC disease is not well characterized. The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease. Procedure: We retrospectively reviewed 71 inpatient episodes of ACS in patients with hemoglobin SC disease over a 20-year period. Continuous and categorical data from index cases were compared with that from 71 control cases of ACS in patients with hemoglobin SS disease. Results: Median length of hospitalization was shorter for hemoglobin SC episodes when compared to hemoglobin SS episodes (3.0 vs. 5.0 days, P<0.001). In comparison to hemoglobin SS patients, a greater proportion of hemoglobin SC patients had a previous history of asthma or wheezing (50.7 vs. 33.8%, OR=2.01 [1.02-3.96], P=0.041) and a respiratory complaint of wheeze (11.3 vs. 2.8%, OR=4.38 [0.90-21.4], P=0.049). In our multivariate regression model, time to ACS diagnosis and total number of days of oxygen supplementation were independent predictors of length of hospitalization in both hemoglobin SC and SS episodes of ACS. Conclusions: ACS appears to be less severe in children with hemoglobin SC disease compared to that in children with SS disease. Asthma and wheezing may represent more significant risk factors for the development of ACS in children with hemoglobin SC disease.

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