Acute colitis produced by chemotactic peptides in rats and mice

J. F. Chester, J. S. Ross, R. A. Malt, S. A. Weitzman

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Colonic inflammation was produced in rats and mice by peptides chemotactic for polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP) and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a compound with less chemotactic activity, caused much less inflammation. In mice, rectal instillation of FNLP caused dose-dependent acute mucosal inflammation which persisted for longer than 12 hours. Twice-weekly rectal instillation of FNLP provided a model of colitis based on neutrophil chemotaxis.

Original languageEnglish (US)
Pages (from-to)284-290
Number of pages7
JournalAmerican Journal of Pathology
Volume121
Issue number2
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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