Abstract
Colonic inflammation was produced in rats and mice by peptides chemotactic for polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP) and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a compound with less chemotactic activity, caused much less inflammation. In mice, rectal instillation of FNLP caused dose-dependent acute mucosal inflammation which persisted for longer than 12 hours. Twice-weekly rectal instillation of FNLP provided a model of colitis based on neutrophil chemotaxis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 284-290 |
| Number of pages | 7 |
| Journal | American Journal of Pathology |
| Volume | 121 |
| Issue number | 2 |
| State | Published - 1985 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine