TY - JOUR
T1 - Acute cortisol administration triggers craving in individuals with cocaine dependence.
AU - Elman, Igor
AU - Lukas, Scott E.
AU - Karlsgodt, Katherine H.
AU - Gasic, Gregory P.
AU - Breiter, Hans C.
PY - 2003
Y1 - 2003
N2 - Stress is often mentioned as a factor in the development of drug abuse.Twelve cocaine dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses, in a double-blind, counterbalanced fashion. Self-reports of mood states were collected prior to, during, and 20 minutes after each bolus was administered. Cortisol produced significant increases in craving while cocaine significantly elevated all subjective ratings (ie, craving, high, rush, and low). These pilot data suggest that cortisol can induce a state that is associated with drug abuse.
AB - Stress is often mentioned as a factor in the development of drug abuse.Twelve cocaine dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses, in a double-blind, counterbalanced fashion. Self-reports of mood states were collected prior to, during, and 20 minutes after each bolus was administered. Cortisol produced significant increases in craving while cocaine significantly elevated all subjective ratings (ie, craving, high, rush, and low). These pilot data suggest that cortisol can induce a state that is associated with drug abuse.
UR - http://www.scopus.com/inward/record.url?scp=4644363727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644363727&partnerID=8YFLogxK
M3 - Article
C2 - 14608241
AN - SCOPUS:4644363727
SN - 0048-5764
VL - 37
SP - 84
EP - 89
JO - Psychopharmacology Bulletin
JF - Psychopharmacology Bulletin
IS - 3
ER -
