Acute EEG findings in children with febrile status epilepticus: Results of the FEBSTAT study

Douglas R. Nordli*, Solomon L. Moshé, Shlomo Shinnar, Dale C. Hesdorffer, Yoshimi Sogawa, John M. Pellock, Darrell V. Lewis, L. Matthew Frank, Ruth C. Shinnar, Shumei Sun

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Objective: The FEBSTAT (Consequences of Prolonged Febrile Seizures) study is prospectively addressing the relationships among serial EEG, MRI, and clinical follow-up in a cohort of children followed from the time of presentation with febrile status epilepticus (FSE). Methods: We recruited 199 children with FSE within 72 hours of presentation. Children underwent a detailed history, physical examination, MRI, and EEG within 72 hours. All EEGs were read by 2 teams and then conferenced. Associations with abnormal EEG were determined using logistic regression. Interrater reliability was assessed using the k statistic. Results: Of the 199 EEGs, 90 (45.2%) were abnormal with the most common abnormality being focal slowing (n = 47) or attenuation (n = 25); these were maximal over the temporal areas in almost all cases. Epileptiform abnormalities were present in 13 EEGs (6.5%). In adjusted analysis, the odds of focal slowing were significantly increased by focal FSE (odds ratio [OR] = 5.08) and hippocampal T2 signal abnormality (OR = 3.50) and significantly decreased with high peak temperature (OR = 0.18). Focal EEG attenuation was also associated with hippocampal T2 signal abnormality (OR = 3.3). Conclusions: Focal EEG slowing or attenuation are present in EEGs obtainedwithin 72 hours of FSE in a substantial proportion of children and are highly associated with MRI evidence of acute hippocampal injury. These findings may be a sensitive and readily obtainable marker of acute injury associated with FSE.

Original languageEnglish (US)
Pages (from-to)2180-2186
Number of pages7
JournalNeurology
Volume79
Issue number22
DOIs
StatePublished - Nov 27 2012

ASJC Scopus subject areas

  • Clinical Neurology

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    Nordli, D. R., Moshé, S. L., Shinnar, S., Hesdorffer, D. C., Sogawa, Y., Pellock, J. M., Lewis, D. V., Frank, L. M., Shinnar, R. C., & Sun, S. (2012). Acute EEG findings in children with febrile status epilepticus: Results of the FEBSTAT study. Neurology, 79(22), 2180-2186. https://doi.org/10.1212/WNL.0b013e3182759766