Acute kidney injury following cardiopulmonary bypass

D. S. Wheeler, C. L. Dent, P. Devarajan, N. W. Kooy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Core Messages: Cardiopulmonary bypass is a significant risk factor for acute kidney injury (AKI) in children with congenital heart disease. AKI is a significant and independent risk factor for increased morbidity and mortality in critically ill patients. The traditional definitions of acute renal failure that rely on changes in serum creatinine alone are no longer valid, as even small increases in serum creatinine are associated with excess morbidity and mortality in critically ill patients. The concentrations of urinary NGAL, IL-18, and KIM-1, and serum NGAL and cystatin C are emerging as novel, early biomarkers of AKI in children following cardiopulmonary bypass. The treatment of AKI is largely supportive, though early recognition is important. Timing of treatment (i.e., renal replacement therapy) may be crucial to assure the best possible outcome.

Original languageEnglish (US)
Title of host publicationPediatric Nephrology in the ICU
PublisherSpringer Berlin Heidelberg
Pages262-273
Number of pages12
ISBN (Print)9783540744238
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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