Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus

Rupesh Raina*, Rolla Abu-Arja, Sidharth Sethi, Richa Dua, Ronith Chakraborty, James T. Dibb, Rajit K. Basu, John Bissler, Melvin Bonilla Felix, Patrick Brophy, Timothy Bunchman, Khalid Alhasan, Dieter Haffner, Yap Hui Kim, Christopher Licht, Mignon McCulloch, Shina Menon, Ali Mirza Onder, Prajit Khooblall, Amrit KhooblallVeronika Polishchuk, Hemalatha Rangarajan, Azmeri Sultana, Clifford Kashtan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Hematopoietic cell transplantation (HCT) is a common therapy for the treatment of neoplastic and metabolic disorders, hematological diseases, and fatal immunological deficiencies. HCT can be subcategorized as autologous or allogeneic, with each modality being associated with their own benefits, risks, and post-transplant complications. One of the most common complications includes acute kidney injury (AKI). However, diagnosing HCT patients with AKI early on remains quite difficult. Therefore, this evidence-based guideline, compiled by the Pediatric Continuous Renal Replacement Therapy (PCRRT) working group, presents the various factors that contribute to AKI and recommendations regarding optimization of therapy with minimal complications in HCT patients.

Original languageEnglish (US)
Pages (from-to)1179-1203
Number of pages25
JournalPediatric Nephrology
Volume37
Issue number6
DOIs
StatePublished - Jun 2022
Externally publishedYes

Keywords

  • Acute kidney injury
  • Bone marrow transplant
  • Hematopoietic cell transplantation
  • KRT
  • Pediatrics
  • Transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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