Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones

John Anastasi*, Mark J. Pettenati, Michelle M. Le Beau, Hau C. Kwaan, Susan C. Weil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalAmerican Journal of Hematology
Volume29
Issue number1
DOIs
StatePublished - Sep 1988

Keywords

  • chromosomes
  • lymphoproliferative disease
  • myeloproliferative disease

ASJC Scopus subject areas

  • Hematology

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