Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones

John Anastasi; Mark J. Pettenati; Michelle M. Le Beau; Hau C. Kwaan; Susan C. Weil

doi:10.1002/ajh.2830290108

Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones

John Anastasi^*, Mark J. Pettenati, Michelle M. Le Beau, Hau C. Kwaan, Susan C. Weil

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.

Original language	English (US)
Pages (from-to)	33-37
Number of pages	5
Journal	American Journal of Hematology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830290108
State	Published - Sep 1988
Externally published	Yes

Funding

Keywords

chromosomes
lymphoproliferative disease
myeloproliferative disease

ASJC Scopus subject areas

Hematology

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title = "Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones",

abstract = "A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.",

keywords = "chromosomes, lymphoproliferative disease, myeloproliferative disease",

author = "John Anastasi and Pettenati, {Mark J.} and {Le Beau}, {Michelle M.} and Kwaan, {Hau C.} and Weil, {Susan C.}",

year = "1988",

month = sep,

doi = "10.1002/ajh.2830290108",

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T1 - Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera

T2 - Cytogenetic analysis reveals two distinct abnormal clones

AU - Anastasi, John

AU - Pettenati, Mark J.

AU - Le Beau, Michelle M.

AU - Kwaan, Hau C.

AU - Weil, Susan C.

PY - 1988/9

Y1 - 1988/9

N2 - A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.

AB - A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.

KW - chromosomes

KW - lymphoproliferative disease

KW - myeloproliferative disease

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Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones

Abstract

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