Acute myeloid leukemia and myelodysplasia following intensive chemotherapy for breast cancer

S. Roman-Unfer, J. D. Bitran*, S. Hanauer, L. Johnson, D. Rita, C. Booth, K. Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Two major classes of therapy-related acute myeloid leukemias (t-AML) and myelodysplastic syndromes (t-MDS) have been described following the use of conventional doses of alkylating agents and epipodophyllotoxins. They are characterized by distinct clinical presentations and chromosomal abnormalities. We report 2 cases of t-AML and 1 case of t-MDS in 3 out of 36 women who underwent high-dose chemotherapy and attempted ABMT for breast cancer. Two patients developed t-AML 4 and 8 months following the initiation of high-dose chemotherapy with or without ABMT. The third patient developed t-MDS 23 months following dose-intensive chemotherapy and ABMT. Cytogenetic studies of the marrow metaphase chromosomes from the two patients who developed t-AML, including FISH analysis in 1 patient, showed a t(9;11)(p22,q23) and abnormal chromosome 6 (ring chromosome). Neither patient had a preleukemic phase, Cytogenetic studies from the third patient who developed t-MDS showed abnormalities of chromosome 5 (-5) and a derivative of chromosome 17. The use of multiple chemotherapeutic agents in all 3 patients makes it difficult to attribute the development of these cases of t-MDS/t-AML to a single chemotherapeutic agent. The possible role of dose-intensive chemotherapy in the development of these secondary malignancies is discussed.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalBone Marrow Transplantation
Volume16
Issue number1
StatePublished - Jan 1 1995

Keywords

  • ABMT
  • Alkylating agents
  • Breast cancer
  • t-AML
  • t-MDS

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Roman-Unfer, S., Bitran, J. D., Hanauer, S., Johnson, L., Rita, D., Booth, C., & Chen, K. (1995). Acute myeloid leukemia and myelodysplasia following intensive chemotherapy for breast cancer. Bone Marrow Transplantation, 16(1), 163-168.