Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all

Maximilian Stahl, Martin S. Tallman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the treatment of acute promyelocytic leukemia (APL). More than 80–90% of patients are expected to be cured with a combination of ATRA, ATO and/or chemotherapy. In this review, we focus on the remaining obstacles to a cure for all patients with APL. We review the issue of early death and coagulopathy and discuss the particular challenges in the care of patients with high-risk APL and patients with relapsed APL. We also give recommendations and highlight ongoing efforts to improve the persistently high early death rate and the outcomes of high risk and relapsed APL patients.

Original languageEnglish (US)
Pages (from-to)3107-3115
Number of pages9
JournalLeukemia and Lymphoma
Volume60
Issue number13
DOIs
StatePublished - Nov 10 2019

Keywords

  • APL
  • ATRA
  • cure

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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