Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)

doi:10.1371/journal.pone.0266985

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.

Original language	English (US)
Article number	e0266985
Journal	PloS one
Volume	18
Issue number	1 January
DOIs	https://doi.org/10.1371/journal.pone.0266985
State	Published - Jan 2023

Funding

KC is supported by VA MVP000 and CIPHER. DAH is supported by National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) UL1TR002240. YL is supported by NIH/NCATS U01TR003528 and NIH National Library of Medicine (NLM) 1R01LM013337. MM is supported by Clinical and Translational Science Award (CTSA) UL1 TR001857. DLM is supported by NIH/NCATS CTSA UL1-TR001878 (University of Pennsylvania). LPP is supported by CTSA Award UL1TR002366. SV is supported by NIH/NLM R01LM012095 and NIH/ NCATS UL1TR001857. GMW is supported by NIH/ NCATS UL1TR002541, NIH/NCATS UL1TR000005, NIH/NLM R01LM013345, and NIH National Human Genome Research Institute (NHGRI) 3U01HG008685-05S2. ZX is supported by NIH National Institute of Neurological Disorders and Stroke (NINDS) R01NS098023. Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0266985

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@article{f8f8e8bb4cd949aa917037e51f5500ca,

title = "Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium",

abstract = "Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.",

author = "{The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)} and Arthur Orieux and Thomas Fert{\'e} and Vianney Jouhet and Aaron, {James R.} and Giuseppe Agapito and Adem Albayrak and Giuseppe Albi and Mario Alessiani and Anna Alloni and Amendola, {Danilo F.} and Fran{\c c}ois Angoulvant and Anthony, {Li L.L.J.} and Aronow, {Bruce J.} and Fatima Ashraf and Andrew Atz and Paul Avillach and Panickan, {Vidul Ayakulangara} and Azevedo, {Paula S.} and James Balshi and Ashley Batugo and Beaulieu-Jones, {Brett K.} and Beau-Lieu-Jones, {Brendin R.} and Bell, {Douglas S.} and Antonio Bellasi and Riccardo Bellazzi and Vincent Benoit and Michele Beraghi and Bernal-Sobrino, {Jos{\'e} Luis} and M{\'e}lodie Bernaux and Romain Bey and Surbhi Bhatnagar and Alvar Blanco-Mart{\'i}nez and Martin Boeker and Bonzel, {Clara Lea} and John Booth and Silvano Bosari and Bourgeois, {Florence T.} and Bradford, {Robert L.} and Brat, {Gabriel A.} and St{\'e}phane Br{\'e}ant and Brown, {Nicholas W.} and Raffaele Bruno and Bryant, {William A.} and Mauro Bucalo and Emily Bucholz and Anita Burgun and Tianxi Cai and Yuan Luo and Chengsheng Mao and Sanchez-Pinto, {L. Nelson}",

note = "Publisher Copyright: Copyright: {\textcopyright} 2023 Moal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2023",

month = jan,

doi = "10.1371/journal.pone.0266985",

language = "English (US)",

volume = "18",

journal = "PloS one",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "1 January",

}

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium. / The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE).
In: PloS one, Vol. 18, No. 1 January, e0266985, 01.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population

T2 - International observational federated study based on electronic health records through the 4CE consortium

AU - The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)

AU - Orieux, Arthur

AU - Ferté, Thomas

AU - Jouhet, Vianney

AU - Aaron, James R.

AU - Agapito, Giuseppe

AU - Albayrak, Adem

AU - Albi, Giuseppe

AU - Alessiani, Mario

AU - Alloni, Anna

AU - Amendola, Danilo F.

AU - Angoulvant, François

AU - Anthony, Li L.L.J.

AU - Aronow, Bruce J.

AU - Ashraf, Fatima

AU - Atz, Andrew

AU - Avillach, Paul

AU - Panickan, Vidul Ayakulangara

AU - Azevedo, Paula S.

AU - Balshi, James

AU - Batugo, Ashley

AU - Beaulieu-Jones, Brett K.

AU - Beau-Lieu-Jones, Brendin R.

AU - Bell, Douglas S.

AU - Bellasi, Antonio

AU - Bellazzi, Riccardo

AU - Benoit, Vincent

AU - Beraghi, Michele

AU - Bernal-Sobrino, José Luis

AU - Bernaux, Mélodie

AU - Bey, Romain

AU - Bhatnagar, Surbhi

AU - Blanco-Martínez, Alvar

AU - Boeker, Martin

AU - Bonzel, Clara Lea

AU - Booth, John

AU - Bosari, Silvano

AU - Bourgeois, Florence T.

AU - Bradford, Robert L.

AU - Brat, Gabriel A.

AU - Bréant, Stéphane

AU - Brown, Nicholas W.

AU - Bruno, Raffaele

AU - Bryant, William A.

AU - Bucalo, Mauro

AU - Bucholz, Emily

AU - Burgun, Anita

AU - Cai, Tianxi

AU - Luo, Yuan

AU - Mao, Chengsheng

AU - Sanchez-Pinto, L. Nelson

N1 - Publisher Copyright: Copyright: © 2023 Moal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2023/1

Y1 - 2023/1

N2 - Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.

AB - Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.

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DO - 10.1371/journal.pone.0266985

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VL - 18

JO - PloS one

JF - PloS one

IS - 1 January

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ER -

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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