Acute time to response in the Treatment for Adolescents with Depression Study (TADS)

Christopher Kratochvil*, Graham Emslie, Susan Silva, Steve McNulty, John Walkup, John Curry, Mark Reinecke, Benedetto Vitiello, Paul Rohde, Nora Feeny, Charles Casat, Sanjeev Pathak, Elizabeth Weller, Diane May, Taryn Mayes, Michele Robins, John March

*Corresponding author for this work

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

OBJECTIVE: To examine the time to response for both pharmacotherapy and psychotherapy in the Treatment for Adolescents with Depression Study (TADS). METHOD: Adolescents (N = 439, ages 12 to 17 years) with major depressive disorder were randomized to fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or pill placebo (PBO). Defining response as very much improved or much improved on the Clinical Global Impression- Improvement Scale (CGI-I), survival analyses using Cox proportional hazards models, and Kaplan-Meier curves were conducted to evaluate time to first response and time to stable response for subjects receiving pharmacotherapy (COMB, FLX, PBO) as well as for subjects receiving CBT (COMB, CBT). Direct comparisons between pharmacotherapy and CBT were not made because of differences in visit schedules. RESULTS: Based on pharmacotherapist CGI-I scores, COMB and FLX showed faster onset of benefit than PBO on time to response and time to stable response (p < .001), and COMB was faster than FLX on time to stable response (p = .034). The probability of sustained early response was approximately threefold greater for COMB than PBO, twofold greater for FLX than PBO, and 1.5-fold greater for COMB than FLX. On the psychotherapist CGI-I scores, both first response and stable response occurred faster in COMB than CBT (p < .001), with a probability of sustained early response approximately threefold greater for COMB than CBT. CONCLUSIONS: In the acute treatment of depressed adolescents, FLX and COMB accelerate response relative to PBO, and COMB accelerates response relative to CBT alone. Copyright 2006

Original languageEnglish (US)
Pages (from-to)1412-1418
Number of pages7
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume45
Issue number12
DOIs
StatePublished - Dec 1 2006

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Fluoxetine
Cognitive Therapy
Depression
Placebos
Drug Therapy
Psychotherapy
Therapeutics
Reaction Time
Major Depressive Disorder
Survival Analysis
Proportional Hazards Models
Appointments and Schedules

Keywords

  • Depression
  • Time to response
  • Treatment

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Kratochvil, Christopher ; Emslie, Graham ; Silva, Susan ; McNulty, Steve ; Walkup, John ; Curry, John ; Reinecke, Mark ; Vitiello, Benedetto ; Rohde, Paul ; Feeny, Nora ; Casat, Charles ; Pathak, Sanjeev ; Weller, Elizabeth ; May, Diane ; Mayes, Taryn ; Robins, Michele ; March, John. / Acute time to response in the Treatment for Adolescents with Depression Study (TADS). In: Journal of the American Academy of Child and Adolescent Psychiatry. 2006 ; Vol. 45, No. 12. pp. 1412-1418.
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Kratochvil, C, Emslie, G, Silva, S, McNulty, S, Walkup, J, Curry, J, Reinecke, M, Vitiello, B, Rohde, P, Feeny, N, Casat, C, Pathak, S, Weller, E, May, D, Mayes, T, Robins, M & March, J 2006, 'Acute time to response in the Treatment for Adolescents with Depression Study (TADS)', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 45, no. 12, pp. 1412-1418. https://doi.org/10.1097/01.chi.0000237710.73755.14

Acute time to response in the Treatment for Adolescents with Depression Study (TADS). / Kratochvil, Christopher; Emslie, Graham; Silva, Susan; McNulty, Steve; Walkup, John; Curry, John; Reinecke, Mark; Vitiello, Benedetto; Rohde, Paul; Feeny, Nora; Casat, Charles; Pathak, Sanjeev; Weller, Elizabeth; May, Diane; Mayes, Taryn; Robins, Michele; March, John.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 45, No. 12, 01.12.2006, p. 1412-1418.

Research output: Contribution to journalArticle

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T1 - Acute time to response in the Treatment for Adolescents with Depression Study (TADS)

AU - Kratochvil, Christopher

AU - Emslie, Graham

AU - Silva, Susan

AU - McNulty, Steve

AU - Walkup, John

AU - Curry, John

AU - Reinecke, Mark

AU - Vitiello, Benedetto

AU - Rohde, Paul

AU - Feeny, Nora

AU - Casat, Charles

AU - Pathak, Sanjeev

AU - Weller, Elizabeth

AU - May, Diane

AU - Mayes, Taryn

AU - Robins, Michele

AU - March, John

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N2 - OBJECTIVE: To examine the time to response for both pharmacotherapy and psychotherapy in the Treatment for Adolescents with Depression Study (TADS). METHOD: Adolescents (N = 439, ages 12 to 17 years) with major depressive disorder were randomized to fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or pill placebo (PBO). Defining response as very much improved or much improved on the Clinical Global Impression- Improvement Scale (CGI-I), survival analyses using Cox proportional hazards models, and Kaplan-Meier curves were conducted to evaluate time to first response and time to stable response for subjects receiving pharmacotherapy (COMB, FLX, PBO) as well as for subjects receiving CBT (COMB, CBT). Direct comparisons between pharmacotherapy and CBT were not made because of differences in visit schedules. RESULTS: Based on pharmacotherapist CGI-I scores, COMB and FLX showed faster onset of benefit than PBO on time to response and time to stable response (p < .001), and COMB was faster than FLX on time to stable response (p = .034). The probability of sustained early response was approximately threefold greater for COMB than PBO, twofold greater for FLX than PBO, and 1.5-fold greater for COMB than FLX. On the psychotherapist CGI-I scores, both first response and stable response occurred faster in COMB than CBT (p < .001), with a probability of sustained early response approximately threefold greater for COMB than CBT. CONCLUSIONS: In the acute treatment of depressed adolescents, FLX and COMB accelerate response relative to PBO, and COMB accelerates response relative to CBT alone. Copyright 2006

AB - OBJECTIVE: To examine the time to response for both pharmacotherapy and psychotherapy in the Treatment for Adolescents with Depression Study (TADS). METHOD: Adolescents (N = 439, ages 12 to 17 years) with major depressive disorder were randomized to fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or pill placebo (PBO). Defining response as very much improved or much improved on the Clinical Global Impression- Improvement Scale (CGI-I), survival analyses using Cox proportional hazards models, and Kaplan-Meier curves were conducted to evaluate time to first response and time to stable response for subjects receiving pharmacotherapy (COMB, FLX, PBO) as well as for subjects receiving CBT (COMB, CBT). Direct comparisons between pharmacotherapy and CBT were not made because of differences in visit schedules. RESULTS: Based on pharmacotherapist CGI-I scores, COMB and FLX showed faster onset of benefit than PBO on time to response and time to stable response (p < .001), and COMB was faster than FLX on time to stable response (p = .034). The probability of sustained early response was approximately threefold greater for COMB than PBO, twofold greater for FLX than PBO, and 1.5-fold greater for COMB than FLX. On the psychotherapist CGI-I scores, both first response and stable response occurred faster in COMB than CBT (p < .001), with a probability of sustained early response approximately threefold greater for COMB than CBT. CONCLUSIONS: In the acute treatment of depressed adolescents, FLX and COMB accelerate response relative to PBO, and COMB accelerates response relative to CBT alone. Copyright 2006

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