Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma

James Rook; Tena Rosser; Jason Fangusaro; Jonathan Finlay

doi:10.1002/pbc.21040

Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma

James Rook, Tena Rosser^*, Jason Fangusaro, Jonathan Finlay

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose-limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood-brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14-year-old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4-6 hr following paclitaxel infusion.

Original language	English (US)
Pages (from-to)	699-700
Number of pages	2
Journal	Pediatric Blood and Cancer
Volume	50
Issue number	3
DOIs	https://doi.org/10.1002/pbc.21040
State	Published - Mar 2008

Keywords

Brain tumor
Encephalopathy
Neurotoxicity
Paclitaxel
Transient

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.21040

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abstract = "Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose-limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood-brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14-year-old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4-6 hr following paclitaxel infusion.",

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AU - Fangusaro, Jason

AU - Finlay, Jonathan

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AB - Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose-limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood-brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14-year-old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4-6 hr following paclitaxel infusion.

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KW - Encephalopathy

KW - Neurotoxicity

KW - Paclitaxel

KW - Transient

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Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma

Abstract

Keywords

ASJC Scopus subject areas

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