Adalimumab Treatment in Patients with Vogt–Koyanagi–Harada Disease

Cristóbal Couto*, Ariel Schlaen, Mercedes Frick, Marina Khoury, Matilde Lopez, Erika Hurtado, Debra Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: To evaluate the clinical outcome and safety of adalimumab in patients with Vogt–Koyanagi–Harada (VKH) disease. Methods: VKH patients treated with adalimumab seen at the University of Buenos Aires were reviewed. Main outcome measures were visual acuity, anterior segment inflammation, optic nerve inflammation (ONI), steroid sparing effect, number of immunosuppressives, and relapses. Results: In total, 14 VKH patients, mean age 23.07 ± 8 years; median of adalimumab treatment 10 months, were analyzed. At start of adalimumab treatment (baseline), median of corticosteroid dose was 20 mg and at 6 months, 4 mg. At baseline, 11 patients were on immunosuppressive treatment and at 6 months only four continued with immunosuppressive therapy. In the 28 eyes, the median of active inflammation was 2 at baseline and 0 after 6 months on adalimumab. Conclusions: Treatment with adalimumab is an effective and safe option, reducing the need for oral corticosteroid and conventional immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalOcular Immunology and Inflammation
Volume26
Issue number3
DOIs
StatePublished - Apr 3 2018

Keywords

  • Adalimumab
  • Vogt–Koyanagi–Harada disease
  • chronic stage
  • clinical outcome
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Fingerprint Dive into the research topics of 'Adalimumab Treatment in Patients with Vogt–Koyanagi–Harada Disease'. Together they form a unique fingerprint.

Cite this