ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD

Robert Vassar*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations

Abstract

In this issue of Neuron, Suh etal. (2013) describe two rare ADAM10 prodomain mutations that cause late-onset Alzheimer@s disease by impairing prodomain chaperone function, attenuating α-secretase activity, and reducing adult hippocampal neurogenesis. These results support both ADAM10 as a therapeutic target and the amyloid hypothesis of Alzheimer@s disease.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalNeuron
Volume80
Issue number2
DOIs
StatePublished - Oct 16 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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