ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations

Denise L. Lind, Shweta Choudhry, Ngim Ung, Elad Ziv, Pedro C. Avila, Keyan Salari, Connie Ha, Elizabeth G. Lovins, Natasha E. Coyle, Sylvette Nazario, Jesus Casal, Alfonso Torres, Jose R. Rodriguez-Santana, Henry Matallana, Craig M. Lilly, Jorge Salas, Moises Selman, Homer A. Boushey, Scott T. Weiss, Rocio ChapelaJean G. Ford, William Rodriguez-Cintron, Edwin K. Silverman, Dean Sheppard, Pui Yan Kwok, Esteban González Burchard*

*Corresponding author for this work

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because In the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes In 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an Important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.

Original languageEnglish (US)
Pages (from-to)1312-1316
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume168
Issue number11
DOIs
StatePublished - Dec 1 2003

Keywords

  • ADAM33
  • Asthma
  • Genetics
  • Latino populations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Lind, D. L., Choudhry, S., Ung, N., Ziv, E., Avila, P. C., Salari, K., Ha, C., Lovins, E. G., Coyle, N. E., Nazario, S., Casal, J., Torres, A., Rodriguez-Santana, J. R., Matallana, H., Lilly, C. M., Salas, J., Selman, M., Boushey, H. A., Weiss, S. T., ... Burchard, E. G. (2003). ADAM33 Is Not Associated with Asthma in Puerto Rican or Mexican Populations. American journal of respiratory and critical care medicine, 168(11), 1312-1316. https://doi.org/10.1164/rccm.200306-877OC