ADAMTS proteases in vascular biology

Juan Carlos Rodríguez-Manzaneque*, Rubén Fernández-Rodríguez, Francisco Javier Rodríguez-Baena, M. Luisa Iruela-Arispe

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases comprise the most recently discovered branch of the extracellular metalloenzymes. Research during the last 15. years, uncovered their association with a variety of physiological and pathological processes including blood coagulation, tissue repair, fertility, arthritis and cancer. Importantly, a frequent feature of ADAMTS enzymes relates to their effects on vascular-related phenomena, including angiogenesis. Their specific roles in vascular biology have been clarified by information on their expression profiles and substrate specificity. Through their catalytic activity, ADAMTS proteases modify rather than degrade extracellular proteins. They predominantly target proteoglycans and glycoproteins abundant in the basement membrane, therefore their broad contributions to the vasculature should not come as a surprise. Furthermore, in addition to their proteolytic functions, non-enzymatic roles for ADAMTS have also been identified expanding our understanding on the multiple activities of these enzymes in vascular-related processes.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalMatrix Biology
Volume44-46
DOIs
StatePublished - May 1 2015

Keywords

  • ADAMTS
  • Angiogenesis
  • Extracellular proteolysis
  • Vasculature

ASJC Scopus subject areas

  • Molecular Biology

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