Adaptations in endocannabinoid signaling in response to repeated homotypic stress: A novel mechanism for stress habituation

Sachin Patel*, Cecilia J. Hillard

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations

Abstract

Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic stress induce anxious and depressive phenotypes and are used to study the pathophysiology of affective disorders. Here we discuss data demonstrating that repeated homotypic stress produces temporally and anatomically distinct changes in endocannabinoid signaling components within stress-responsive brain regions. We also present evidence describing the neural and behavioral correlates of these adaptations in endocannabinoid signaling. These data support a role for endocannabinoid signaling in the central nervous system response to chronic, homotypic stress, and specifically in the process of stress-response habituation. The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed.

Original languageEnglish (US)
Pages (from-to)2821-2829
Number of pages9
JournalEuropean Journal of Neuroscience
Volume27
Issue number11
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • 2-arachidonoylglycerol
  • Anandamide
  • Anxiety
  • Cannabinoid
  • CB1
  • N-arachidonylethanolamine

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Adaptations in endocannabinoid signaling in response to repeated homotypic stress: A novel mechanism for stress habituation'. Together they form a unique fingerprint.

Cite this