TY - JOUR
T1 - Adapting proteostasis for disease intervention
AU - Balch, William E.
AU - Morimoto, Richard I.
AU - Dillin, Andrew
AU - Kelly, Jeffery W.
PY - 2008/2/15
Y1 - 2008/2/15
N2 - The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.
AB - The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.
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U2 - 10.1126/science.1141448
DO - 10.1126/science.1141448
M3 - Review article
C2 - 18276881
AN - SCOPUS:39349083915
SN - 0036-8075
VL - 319
SP - 916
EP - 919
JO - Science
JF - Science
IS - 5865
ER -