Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling by Angiotensin II

Marcel Egger*, Andrea A. Domenighetti

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling are not precisely known. We review this question, as well as acute Ang II-mediated modulation of ECC. In addition, we discuss adaptive/maladaptive modulation of cardiomyocyte ECC under chronic endogenous Ang II overproduction in the heart induced by local overexpression of the of the renin-angiotensin system in the mouse.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume20
Issue number3
DOIs
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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