Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; A randomized controlled trial

J. M. Spergel*, M. Boguniewicz, Amy Paller, A. A. Hebert, P. R. Gallagher, C. McCormick, A. Parneix-Spake, T. Hultsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Combination therapy with pimecrolimus cream 1%, a topical calcineurin inhibitor (TCI), and fluticasone propionate cream 0.05% (FP), a mid-potency topical corticosteroid, may have a synergistic effect for treatment of atopic dermatitis (AD) because their mechanism of action differs. Objectives: To assess the efficacy of concomitant pimecrolimus twice daily/FP once daily vs. vehicle twice daily/FP once daily in patients with severe AD. Methods: An exploratory, 2-week, double-blind, randomized, within-patient study was conducted (n = 45). Two target areas of similar severity, size and location were assessed. Assessments included the modified Eczema Area and Severity Index (0-12 scale) (primary variable), localized investigator global assessment (0-4 scale) and Patients' Self-Assessment of Disease Severity (0-4 scale). Results: Data for all variables were similar for the TCI/FP and vehicle/FP treatments. Conclusions: The efficacy observed for treatment of severe AD flares with this TCI/FP combination regimen was equivalent to that of vehicle/FP.

Original languageEnglish (US)
Pages (from-to)378-381
Number of pages4
JournalBritish Journal of Dermatology
Volume157
Issue number2
DOIs
StatePublished - Aug 1 2007

Keywords

  • Atopic dermatitis
  • Combination therapy
  • Fluticasone
  • Pimecrolimus

ASJC Scopus subject areas

  • Dermatology

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