Addressing ethical challenges in US-based HIV phylogenetic research

Liza Dawson; Nanette Benbow; Faith E. Fletcher; Seble Kassaye; Amy Killelea; Stephen R. Latham; Lisa M. Lee; Thomas Leitner; Susan J. Little; Sanjay R. Mehta; Omar Martinez; Brian Minalga; Art Poon; Stuart Rennie; Jeremy Sugarman; Patricia Sweeney; Lucia V. Torian; Joel O. Wertheim

doi:10.1093/infdis/jiaa107

Addressing ethical challenges in US-based HIV phylogenetic research

Liza Dawson^*, Nanette Benbow, Faith E. Fletcher, Seble Kassaye, Amy Killelea, Stephen R. Latham, Lisa M. Lee, Thomas Leitner, Susan J. Little, Sanjay R. Mehta, Omar Martinez, Brian Minalga, Art Poon, Stuart Rennie, Jeremy Sugarman, Patricia Sweeney, Lucia V. Torian, Joel O. Wertheim

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

In recent years, phylogenetic analysis of HIV sequence data has been used in research studies to investigate transmission patterns between individuals and groups, including analysis of data from HIV prevention clinical trials, in molecular epidemiology, and in public health surveillance programs. Phylogenetic analysis can provide valuable information to inform HIV prevention efforts, but it also has risks, including stigma and marginalization of groups, or potential identification of HIV transmission between individuals. In response to these concerns, an interdisciplinary working group was assembled to address ethical challenges in US-based HIV phylogenetic research. The working group developed recommendations regarding (1) study design; (2) data security, access, and sharing; (3) legal issues; (4) community engagement; and (5) communication and dissemination. The working group also identified areas for future research and scholarship to promote ethical conduct of HIV phylogenetic research.

Original language	English (US)
Pages (from-to)	1997-2006
Number of pages	10
Journal	Journal of Infectious Diseases
Volume	222
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiaa107
State	Published - Dec 15 2020

Keywords

Ethics
HIV/AIDS
Phylogenetics
Public health

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiaa107

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Dawson, L., Benbow, N., Fletcher, F. E., Kassaye, S., Killelea, A., Latham, S. R., Lee, L. M., Leitner, T., Little, S. J., Mehta, S. R., Martinez, O., Minalga, B., Poon, A., Rennie, S., Sugarman, J., Sweeney, P., Torian, L. V., & Wertheim, J. O. (2020). Addressing ethical challenges in US-based HIV phylogenetic research. Journal of Infectious Diseases, 222(12), 1997-2006. https://doi.org/10.1093/infdis/jiaa107

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abstract = "In recent years, phylogenetic analysis of HIV sequence data has been used in research studies to investigate transmission patterns between individuals and groups, including analysis of data from HIV prevention clinical trials, in molecular epidemiology, and in public health surveillance programs. Phylogenetic analysis can provide valuable information to inform HIV prevention efforts, but it also has risks, including stigma and marginalization of groups, or potential identification of HIV transmission between individuals. In response to these concerns, an interdisciplinary working group was assembled to address ethical challenges in US-based HIV phylogenetic research. The working group developed recommendations regarding (1) study design; (2) data security, access, and sharing; (3) legal issues; (4) community engagement; and (5) communication and dissemination. The working group also identified areas for future research and scholarship to promote ethical conduct of HIV phylogenetic research.",

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Dawson, L, Benbow, N, Fletcher, FE, Kassaye, S, Killelea, A, Latham, SR, Lee, LM, Leitner, T, Little, SJ, Mehta, SR, Martinez, O, Minalga, B, Poon, A, Rennie, S, Sugarman, J, Sweeney, P, Torian, LV & Wertheim, JO 2020, 'Addressing ethical challenges in US-based HIV phylogenetic research', Journal of Infectious Diseases, vol. 222, no. 12, pp. 1997-2006. https://doi.org/10.1093/infdis/jiaa107

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AU - Kassaye, Seble

AU - Killelea, Amy

AU - Latham, Stephen R.

AU - Lee, Lisa M.

AU - Leitner, Thomas

AU - Little, Susan J.

AU - Mehta, Sanjay R.

AU - Martinez, Omar

AU - Minalga, Brian

AU - Poon, Art

AU - Rennie, Stuart

AU - Sugarman, Jeremy

AU - Sweeney, Patricia

AU - Torian, Lucia V.

AU - Wertheim, Joel O.

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Addressing ethical challenges in US-based HIV phylogenetic research

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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