Addressing ethical challenges in US-based HIV phylogenetic research

Liza Dawson*, Nanette Benbow, Faith E. Fletcher, Seble Kassaye, Amy Killelea, Stephen R. Latham, Lisa M. Lee, Thomas Leitner, Susan J. Little, Sanjay R. Mehta, Omar Martinez, Brian Minalga, Art Poon, Stuart Rennie, Jeremy Sugarman, Patricia Sweeney, Lucia V. Torian, Joel O. Wertheim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In recent years, phylogenetic analysis of HIV sequence data has been used in research studies to investigate transmission patterns between individuals and groups, including analysis of data from HIV prevention clinical trials, in molecular epidemiology, and in public health surveillance programs. Phylogenetic analysis can provide valuable information to inform HIV prevention efforts, but it also has risks, including stigma and marginalization of groups, or potential identification of HIV transmission between individuals. In response to these concerns, an interdisciplinary working group was assembled to address ethical challenges in US-based HIV phylogenetic research. The working group developed recommendations regarding (1) study design; (2) data security, access, and sharing; (3) legal issues; (4) community engagement; and (5) communication and dissemination. The working group also identified areas for future research and scholarship to promote ethical conduct of HIV phylogenetic research.

Original languageEnglish (US)
Pages (from-to)1997-2006
Number of pages10
JournalJournal of Infectious Diseases
Volume222
Issue number12
DOIs
StatePublished - Dec 15 2020

Keywords

  • Ethics
  • HIV/AIDS
  • Phylogenetics
  • Public health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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