Adenoviral virotherapy for malignant brain tumors

Suvobroto Nandi, Maciej S. Lesniak

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Glioblastoma multiforme is the most common form of primary brain cancer. In the past decade, virotherapy of tumors has gained credence, particularly in glioma management, as these tumors are not completely resectable and tend to micro-metastasize. Adenoviral vectors have an advantage over other viral vectors in that they are relatively non-toxic and do not integrate in the genome. However, the lack of coxsackie and adenovirus receptors on surface of gliomas provides for inefficient transduction of wild-type adenoviral vectors in these tumors. By targeting receptors that are overexpressed in gliomas, modified adenoviral constructs have been shown to efficiently infect glioma cells. In addition, by taking advantage of tumor-specific promoter elements, oncolytic adenoviral vectors offer the promise of selective tumor-specific replication. This dual targeting strategy has enabled specificity in both laboratory and pre-clinical settings. This review examines current trends in adenoviral virotherapy of gliomas, with an emphasis on targeting modalities and future clinical applications.

Original languageEnglish (US)
Pages (from-to)737-747
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume9
Issue number6
DOIs
StatePublished - Jun 2009

Keywords

  • Brain tumor
  • Gene therapy
  • Glioma
  • Oncolytic adenovirus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Adenoviral virotherapy for malignant brain tumors'. Together they form a unique fingerprint.

Cite this