Adenovirus

Michael G. Ison, Randall T. Hayden

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Adenoviruses are a highly prevalent infection that can cause a range of clinical syndromes in immunocompromised patients, ranging from localized disease of the respiratory tract, gastrointestinal tract, or urinary tract to disseminated disease. Adenovirus infections may develop in this unique population as the result of primary infection or reactivation of latent virus. Disease can be potentially progressive with high rates of mortality in patients with pneumonia and disseminated disease. Fortunately, cidofovir and its lipid ester, brincidofovir, appear to be effective for the treatment of adenovirus, although neither is specifically approved for this indication. Adenovirus should always be considered when immunocompromised patients present with any clinical syndrome that could be compatible with adenoviral infection. Once disease is suspected, cultures or molecular testing of appropriate specimens should be obtained and blood should be sent for adenovirus polymerase chain reaction (PCR) whenever adenovirus is suspected. Monitoring of quantitative viral loads in blood is helpful in predicting response to therapy with a significant drop (>1 log) associated with a higher probability of clinical response.

Original languageEnglish (US)
JournalMicrobiology spectrum
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2016

Fingerprint

Adenoviridae
Immunocompromised Host
Infection
blood
Adenoviridae Infections
Respiratory Tract Diseases
pneumonia
Viral Load
Urinary Tract
reactivation
polymerase chain reaction
ester
Gastrointestinal Tract
Pneumonia
virus
Esters
lipid
Viruses
Lipids
mortality

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

Cite this

Ison, Michael G. ; Hayden, Randall T. / Adenovirus. In: Microbiology spectrum. 2016 ; Vol. 4, No. 4.
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Adenovirus. / Ison, Michael G.; Hayden, Randall T.

In: Microbiology spectrum, Vol. 4, No. 4, 01.08.2016.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Adenovirus

AU - Ison, Michael G.

AU - Hayden, Randall T.

PY - 2016/8/1

Y1 - 2016/8/1

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AB - Adenoviruses are a highly prevalent infection that can cause a range of clinical syndromes in immunocompromised patients, ranging from localized disease of the respiratory tract, gastrointestinal tract, or urinary tract to disseminated disease. Adenovirus infections may develop in this unique population as the result of primary infection or reactivation of latent virus. Disease can be potentially progressive with high rates of mortality in patients with pneumonia and disseminated disease. Fortunately, cidofovir and its lipid ester, brincidofovir, appear to be effective for the treatment of adenovirus, although neither is specifically approved for this indication. Adenovirus should always be considered when immunocompromised patients present with any clinical syndrome that could be compatible with adenoviral infection. Once disease is suspected, cultures or molecular testing of appropriate specimens should be obtained and blood should be sent for adenovirus polymerase chain reaction (PCR) whenever adenovirus is suspected. Monitoring of quantitative viral loads in blood is helpful in predicting response to therapy with a significant drop (>1 log) associated with a higher probability of clinical response.

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