TY - JOUR
T1 - Adherence of polymorphonuclear leukocytes to nylon
T2 - Modulation by prostacyclin (PGI2), corticosteroids, and complement activation
AU - McGillen, J.
AU - Patterson, R.
AU - Phair, J. P.
N1 - Funding Information:
Received for publication June 4, 1979, and in revised form October 30, 1979. This work was supported by funds from the Samuel J. Sackett Endowment and the Upjohn Corporation and by grant no. AI 13668 from the National Institutes of Health. Dr. McGillen was the recipient of an Owen Coon Fellowship. We thank Shirley Ackerman for secretarial assistance and Beverly Morlock for technical assistance. Please address requests for reprints to Dr. J. Phair, Section of Infectious Disease, Department of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611.
PY - 1980
Y1 - 1980
N2 - Effects of in vitro addition of prostacyclin (PGI2), hydrocortisone, and zymosan to plasma on adherence of polymorphonuclear leukocytes (PMNLs) to nylon were investigated. PGI2, in nanogram concentrations, and hydrocortisone, in high concentrations, inhibited base-line adherence of PMNLs; zymosan-treated plasma augmented retention of PMNLs by nylon columns. Incubation of plasma with antiserum to C5, hydrocortisone, or PGI2 blocked zymosan-mediated effects. Prostaglandins (PGD2, PGE1, and PGF2(α)) when added in vitro did not alter base-line adherence. PMNLs obtained 4 hr after administration or oral prednisone to volunteers were partially resistant to effects of zymosan-activated plasma.
AB - Effects of in vitro addition of prostacyclin (PGI2), hydrocortisone, and zymosan to plasma on adherence of polymorphonuclear leukocytes (PMNLs) to nylon were investigated. PGI2, in nanogram concentrations, and hydrocortisone, in high concentrations, inhibited base-line adherence of PMNLs; zymosan-treated plasma augmented retention of PMNLs by nylon columns. Incubation of plasma with antiserum to C5, hydrocortisone, or PGI2 blocked zymosan-mediated effects. Prostaglandins (PGD2, PGE1, and PGF2(α)) when added in vitro did not alter base-line adherence. PMNLs obtained 4 hr after administration or oral prednisone to volunteers were partially resistant to effects of zymosan-activated plasma.
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U2 - 10.1093/infdis/141.3.382
DO - 10.1093/infdis/141.3.382
M3 - Article
C2 - 6988525
AN - SCOPUS:0018835281
VL - 141
SP - 382
EP - 388
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -
