Adherence of polymorphonuclear leukocytes to nylon: Modulation by prostacyclin (PGI2), corticosteroids, and complement activation

J. McGillen, R. Patterson, J. P. Phair

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Effects of in vitro addition of prostacyclin (PGI2), hydrocortisone, and zymosan to plasma on adherence of polymorphonuclear leukocytes (PMNLs) to nylon were investigated. PGI2, in nanogram concentrations, and hydrocortisone, in high concentrations, inhibited base-line adherence of PMNLs; zymosan-treated plasma augmented retention of PMNLs by nylon columns. Incubation of plasma with antiserum to C5, hydrocortisone, or PGI2 blocked zymosan-mediated effects. Prostaglandins (PGD2, PGE1, and PGF2(α)) when added in vitro did not alter base-line adherence. PMNLs obtained 4 hr after administration or oral prednisone to volunteers were partially resistant to effects of zymosan-activated plasma.

Original languageEnglish (US)
Pages (from-to)382-388
Number of pages7
JournalJournal of Infectious Diseases
Volume141
Issue number3
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Adherence of polymorphonuclear leukocytes to nylon: Modulation by prostacyclin (PGI<sub>2</sub>), corticosteroids, and complement activation'. Together they form a unique fingerprint.

Cite this