Adherence to Bürgi-Dunitz stereochemical principles requires significant structural rearrangements in Schiff-base formation: Insights from transaldolase complexes

Keyphrases

• Bond Formation 100%
• Structural Rearrangement 100%
• Stereochemical Hypothesis 100%
• Transaldolase 100%
• Schiff Base Formation 100%
• Aldolase 66%
• Structural Change 33%
• Enzyme Catalysis 33%
• Structural Transformation 33%
• Biocatalysis 33%
• Conformational Change 33%
• Francisella Tularensis 33%
• Engineered Systems 33%
• Catalytic Mechanism 33%
• Nucleophile 33%
• Electrophile 33%
• Keto 33%
• Sugar Phosphate 33%
• Reactive Groups 33%
• Covalent Complex 33%
• Noncovalent Complexes 33%
• Substrate Rotation 33%
• Sedoheptulose 7-phosphate 33%

Biochemistry, Genetics and Molecular Biology

• Aldolase 100%
• Fructose-Bisphosphate Aldolase 100%
• Transaldolase 100%
• Wild Type 50%
• Crystal Structure 50%
• Conformational Change 50%
• Fructose 6-Phosphate 50%
• Biocatalysis 50%
• Enzyme Catalysis 50%
• Sedoheptulose 7-Phosphate 50%
• Francisella Tularensis 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Transaldolase 100%
• Imine 100%
• Fructose Bisphosphate Aldolase 66%
• Nucleophile 33%
• Francisella Tularensis 33%
• Electrophile 33%
• Fructose 6 Phosphate 33%