Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy; Alexis A. Thompson; Jin Shei Lai; Frank J. Penedo; Karen Rychlik; Robert I. Liem

doi:10.1186/s12955-017-0713-x

Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy^*, Alexis A. Thompson, Jin Shei Lai, Frank J. Penedo, Karen Rychlik, Robert I. Liem

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

Original language	English (US)
Article number	136
Journal	Health and Quality of Life Outcomes
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12955-017-0713-x
State	Published - Jul 5 2017

Keywords

Adherence
Beliefs
Health-related quality of life
Hydroxyurea
Patient reported outcomes
Perceptions
Sickle cell disease

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12955-017-0713-x

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Badawy, S. M., Thompson, A. A., Lai, J. S., Penedo, F. J., Rychlik, K., & Liem, R. I. (2017). Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults. Health and Quality of Life Outcomes, 15(1), [136]. https://doi.org/10.1186/s12955-017-0713-x

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abstract = "Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,",

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Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea : A cross-sectional study in adolescents and young adults. / Badawy, Sherif M.; Thompson, Alexis A.; Lai, Jin Shei; Penedo, Frank J.; Rychlik, Karen; Liem, Robert I.

In: Health and Quality of Life Outcomes, Vol. 15, No. 1, 136, 05.07.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea

T2 - A cross-sectional study in adolescents and young adults

AU - Badawy, Sherif M.

AU - Thompson, Alexis A.

AU - Lai, Jin Shei

AU - Penedo, Frank J.

AU - Rychlik, Karen

AU - Liem, Robert I.

PY - 2017/7/5

Y1 - 2017/7/5

N2 - Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

AB - Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

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KW - Beliefs

KW - Health-related quality of life

KW - Hydroxyurea

KW - Patient reported outcomes

KW - Perceptions

KW - Sickle cell disease

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Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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