Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy; Alexis A. Thompson; Jin Shei Lai; Frank J. Penedo; Karen Rychlik; Robert I. Liem

doi:10.1186/s12955-017-0713-x

Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy^*, Alexis A. Thompson, Jin Shei Lai, Frank J. Penedo, Karen Rychlik, Robert I. Liem

^*Corresponding author for this work

Research output: Contribution to journal › Article

24 Scopus citations

Abstract

Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

Original language	English (US)
Article number	136
Journal	Health and Quality of Life Outcomes
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12955-017-0713-x
State	Published - Jul 5 2017

Keywords

Adherence
Beliefs
Health-related quality of life
Hydroxyurea
Patient reported outcomes
Perceptions
Sickle cell disease

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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Badawy, S. M., Thompson, A. A., Lai, J. S., Penedo, F. J., Rychlik, K., & Liem, R. I. (2017). Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults. Health and Quality of Life Outcomes, 15(1), [136]. https://doi.org/10.1186/s12955-017-0713-x

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abstract = "Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,",

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Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea : A cross-sectional study in adolescents and young adults. / Badawy, Sherif M.; Thompson, Alexis A.; Lai, Jin Shei; Penedo, Frank J.; Rychlik, Karen; Liem, Robert I.

In: Health and Quality of Life Outcomes, Vol. 15, No. 1, 136, 05.07.2017.

Research output: Contribution to journal › Article

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AU - Thompson, Alexis A.

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