Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy*, Alexis A. Thompson, Jin Shei Lai, Frank J. Penedo, Karen Rychlik, Robert I. Liem

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations


Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

Original languageEnglish (US)
Article number136
JournalHealth and Quality of Life Outcomes
Issue number1
StatePublished - Jul 5 2017



  • Adherence
  • Beliefs
  • Health-related quality of life
  • Hydroxyurea
  • Patient reported outcomes
  • Perceptions
  • Sickle cell disease

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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