Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy; Alexis A. Thompson; Jin Shei Lai; Frank J. Penedo; Karen Rychlik; Robert I. Liem

doi:10.1186/s12955-017-0713-x

Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults

Sherif M. Badawy^*, Alexis A. Thompson, Jin Shei Lai, Frank J. Penedo, Karen Rychlik, Robert I. Liem

^*Corresponding author for this work

Research output: Contribution to journal › Article

24 Scopus citations

Abstract

Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,

Original language	English (US)
Article number	136
Journal	Health and Quality of Life Outcomes
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12955-017-0713-x
State	Published - Jul 5 2017

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Keywords

Adherence
Beliefs
Health-related quality of life
Hydroxyurea
Patient reported outcomes
Perceptions
Sickle cell disease

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Cite this

Badawy, S. M., Thompson, A. A., Lai, J. S., Penedo, F. J., Rychlik, K., & Liem, R. I. (2017). Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea: A cross-sectional study in adolescents and young adults. Health and Quality of Life Outcomes, 15(1), [136]. https://doi.org/10.1186/s12955-017-0713-x

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abstract = "Background: Sickle cell disease (SCD) patients have impaired domains of health-related quality of life (HRQOL). Hydroxyurea is safe and efficacious in SCD; however, adherence is suboptimal, and patients' perceptions are poorly understood amongst adolescents and young adults (AYA). Study objectives were to: (1) examine patients' perceptions of SCD and hydroxyurea; and (2) explore the relationship of their perceptions to clinical characteristics, HRQOL domains and hydroxyurea adherence. Methods: Thirty-four SCD patients on hydroxyurea (≥6 months) participated in a single-institution study. Study measures included Brief-Illness Perceptions Questionnaire,",

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Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptions of sickle cell disease and hydroxyurea : A cross-sectional study in adolescents and young adults. / Badawy, Sherif M.; Thompson, Alexis A.; Lai, Jin Shei; Penedo, Frank J.; Rychlik, Karen; Liem, Robert I.

In: Health and Quality of Life Outcomes, Vol. 15, No. 1, 136, 05.07.2017.

Research output: Contribution to journal › Article

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AU - Thompson, Alexis A.

AU - Lai, Jin Shei

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AU - Liem, Robert I.

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10.1186/s12955-017-0713-x