Adherens junction assembly

Sergey Troyanovsky

doi:10.1007/978-94-007-4186-7_5

Adherens junction assembly

Sergey Troyanovsky^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Classical cadherins are a family of transmembrane proteins that mediate cell–cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin domains (EC1). The structure of cadherin adhesive clusters can be modified by other adherens junction proteins including additional transmembrane proteins, nectins and various intracellular proteins that directly or indirectly interact with the intracellular cadherin region. These interactions determine the dynamics and stability of cadherin adhesive structures.

Original language	English (US)
Pages (from-to)	89-108
Number of pages	20
Journal	Subcellular Biochemistry
Volume	60
DOIs	https://doi.org/10.1007/978-94-007-4186-7_5
State	Published - 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-007-4186-7_5

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AB - Classical cadherins are a family of transmembrane proteins that mediate cell–cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin domains (EC1). The structure of cadherin adhesive clusters can be modified by other adherens junction proteins including additional transmembrane proteins, nectins and various intracellular proteins that directly or indirectly interact with the intracellular cadherin region. These interactions determine the dynamics and stability of cadherin adhesive structures.

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Adherens junction assembly

Abstract

ASJC Scopus subject areas

UN SDGs

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