Adhesion and Migration, the Diverse Functions of the Laminin α3 Subunit

Kevin J. Hamill*, Amy S. Paller, Jonathan C.R. Jones

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

The laminins are a secreted family of heterotrimeric molecules essential for basement membrane formation, structure, and function. It is now well established that the α3 subunit of laminins-332, -321, and -311 plays an important role in mediating epidermal-dermal integrity and is essential for the skin to withstand mechanical stresses. These laminins also regulate cell migration and mechanosignal transduction. This article provides an overview of the gene, transcripts, and protein structures of laminin α3. Also discussed are the proposed functions for the α3 subunit-containing laminins.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalDermatologic clinics
Volume28
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Basement membrane
  • Cell adhesion
  • Cell migration
  • Laminins

ASJC Scopus subject areas

  • Dermatology

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