Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

E. C. Oelsner*, T. D. Pottinger, K. M. Burkart, M. Allison, S. G. Buxbaum, N. N. Hansel, R. Kumar, E. K. Larkin, L. A. Lange, L. R. Loehr, S. J. London, G. T. O'Connor, G. Papanicolaou, M. F. Petrini, D. Rabinowitz, S. Raghavan, S. Redline, B. Thyagarajan, R. P. Tracy, J. B. WilkW. B. White, S. S. Rich, R. G. Barr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalBiomarkers
Volume18
Issue number3
DOIs
StatePublished - May 1 2013

Keywords

  • Genetic polymorphisms
  • Growth factors/cytokines/inflammatory mediators
  • Respiratory disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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