Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: Histology versus magnetic resonance spectroscopy

Alireza Ghotb, Susan M. Noworolski, Erin Madden, Rebecca Scherzer, Aliya Qayyum, Jane Pannell, Linda Ferrell, Marion Peters, Phyllis C. Tien

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Hepatic steatosis is common in persons with HIV and hepatitis C virus (HCV); yet biopsy measurement of steatosis is prone to sampling error. We compared magnetic resonance spectroscopy (MRS) measurement of steatosis to histology in HIV/HCV-coinfected patients and explored the associated adipose tissue and metabolic factors. Methods: Cross-sectional analysis of 42 HIV/HCV-coinfected men and women. Logistic regression analysis identified factors (MRI-measured visceral adipose tissue and abdominal subcutaneous adipose tissue and Homeostasis Model Assessment-estimated insulin resistance) associated with histologic steatosis (≥5% of hepatocytes with fat) and MRS steatosis (≥5% of hepatic fat). Results: MRS steatosis was strongly associated with histologic steatosis, when measured continuously (odds ratio: 10.2 per doubling of MRS-measured hepatic fat; 95% confidence interval: 2.9 to 69.3) and dichotomously (Kappa coefficient = 0.52; P = 0.0007). Four of the 10 with MRS-measured steatosis did not have histologic steatosis; 3 of 9 with histologic steatosis did not have MRS-measured steatosis (67% sensitivity; 88% specificity). Associations of visceral adipose tissue and abdominal subcutaneous adipose tissue were associated with both histologic and MRS-measured steatosis. Insulin resistance was also associated with both. Conclusions: When compared with histology, MRS was similarly associated with adipose tissue and metabolic factors. MRS is a useful noninvasive alternative to biopsy in HIV/HCV coinfection.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume55
Issue number2
DOIs
StatePublished - Oct 1 2010

Keywords

  • Adipose tissue
  • HCV
  • HIV
  • Insulin resistance
  • Magnetic resonance spectroscopy
  • Steatosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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